Benzotriazole: A Versatile Synthetic Auxiliary
Journal Title: Archives of Organic and Inorganic Chemical Sciences - Year 2018, Vol 2, Issue 1
Abstract
Benzotriazole (BtH) is particularly versatile synthetic auxiliary because of its attractive properties. Benzotriazole can be easily inserted into molecules and equally can also act as a good leaving group. This molecule is a weak acid (pKa 8.2) as well as weak base (pKa < 0) and because of this acid-base property of benzotriazole. This molecule also shows not only electron donating but also electron attracting ability, which leads to various synthetic applications. In 1980, benzotriazole was first reported as synthetic auxiliary in organic chemistry [1]. Since then benzotriazole is used in the construction of various monocyclic and bicyclic heterocyclic compounds which are difficult to prepare by other methods [2-5]. Heterocycles are important class of compounds. Benzotriazole extensively used for the synthesis of various heterocycles. 1-Aza- 1,3-bis(triphenyl phosphoranylidene)propane synthesized from N-((1H-benzo[d][1,2,3]triazol-1-yl)methyl)-1,1,1-triphenyH5- phosphanimine and methylene triphenyl phosphorane in presence of n-butyllithium, used as potential building block for the synthesis of heterocycles like 3H-benzo[c] azepine and 2,3-disubstituted pyrroles [6].2-Substituted benzothiazoles are well known for their biological properties with numerous accounts listing their synthesis [7]. Recently, benzotriazole technology was used in water as a one-pot approach to synthesize 2-peptidyl benzothiazole in excellent yield without any detectable racemization [8]. The effectiveness of this approach relies in the fact that it neither required any additional reagents nor catalyst for completion (Figure 1-3).
Authors and Affiliations
Siva S Panda
Keywords
Related Articles
- EP ID EP602952
- DOI 10.32474/AOICS.2018.02.000129
- Views 70
- Downloads 0
Phytochemical, Antimicrobial Potential and Antifungal Activities Stem Bark Extract of Boswellia Ovalifoliolata
This study was carried out with an objective to investigate the antibacterial and antifungal potentials of Stem bark of Boswellia ovalifoliolata (BO). The aim of the study is to assess the antimicrobial activity and to d...
Scientific Substantiation and Methodical Basis For Creating Cards of Determining Potential ifStl Hazards of Sloping Land of Azerbaijan (On The Example Of Akhsuinsky And Ismayilli Districts)
The article examines the issues soil erosion a risk traditionally rapidly growing with agriculture in tropical and semi-arid regions, which is particularly important for its long-term effects on soil productivity, removi...
Novel Stability Indicating RP-HPLC Method for the Simultaneous Estimation of Clindamycin and Adapalene in Pharmaceutical Dosage Forms
A simple, accurate, rapid and precise isocratic stability indicating reversed-phase high-performance liquid chromatographic method has been developed and validated for simultaneous determination of Clindamycin...
On Efficiency of Application of Irrigation Systems With Low Intensity at Azerbaijan’s Slot Land
The study of the world experience and the results of long-term experiments on drip irrigation systems in various climatic and soil conditions shows that the creation of irrigation systems of this type is effective and ec...
Excellent Crystal Coloration and An Extraordinary Improvements of Developing Synthetic Quartz Single Crystals Growth and Defects
The analysis of the impurity content crystals grown in sodium carbonate solution is carried out using flame technique. Colored crystals have been produced from aqueous solutions of potassium carbonate under laboratory co...