Beta-blockers and statins in the context of asthma
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2009, Vol 63, Issue
Abstract
Asthma is a disease with a complex pathogenesis and differentiated clinical picture with airway inflammation in its background. Many cells and cell-released substances are engaged in the course of the disease. The basic treatment strategy in asthma is based on chronic administration of inhaled glucocorticosteroids (with a strong anti-inflammatory effect) and beta2-adrenoreceptor agonists (bronchodilatory effect). Much attention has been recently paid to the effects of other medicines on mechanisms important in the pathogenesis of asthma, including beta-blockers and statins. Many researchers have suggested a potentially useful role of some beta-blockers in chronic asthma therapy, particularly considering their effect on the pharmacodynamics of beta receptors in the bronchi. Moreover, statins, due to their anti-inflammatory and immunomodulatory effects, can also be useful in the management of asthma.
Authors and Affiliations
Joanna Pawlak, Ziemowit Ziętkowski, Anna Bodzenta-Łukaszyk
Keywords
Related Articles
- EP ID EP66412
- DOI -
- Views 159
- Downloads 0
Mezenchymalne komórki zrębu
Mezenchymalne komórki zrębu (MSC) to jedne z najintensywniej badanych komórek w ostatnich latach. Brak swoistych, unikatowych markerów dla komórek pochodzenia mezenchymalnego sprawia, że trudno jest odróżnić komórki MSC...
Autophagy and BNIP3 protein in tumorogenesis
Autophagy is a process necessary for maintaining cell homeostasis in physiological conditions, as well as during certain stresses like nutrients or oxygen deprivation. Autophagy also plays an essential role in tumorigene...
Developmental programming of metabolic diseases – a review of studies on experimental animal models
Growth and development in utero is a complex and dynamic process that requires interaction between the mother organism and the fetus. The delivery of macro – and micronutrients, oxygen and endocrine signals has crucial i...
Biologiczne skutki stresu oksydacyjnego wywołanego działaniem pestycydów
Pestycydy są powszechnie stosowane do ochrony roślin, produktów roślinnych, a także są wykorzystywane w wielu gałęziach przemysłu. Zaliczane są do związków szkodliwych. Mimo istniejących rygorystycznych kontroli ich st...
Nadmierne wytwarzanie śluzu jako mechanizm ochraniający błonę śluzową żołądka w czasie przyjmowania napojów energetycznych przez szczury rasy Wistar
Aim: Energy drinks are the most consumed, socially accepted stimulants in the world. They are drunk by drivers and students, and more often also by adolescents and children. It has been noted that some adverse events are...