Bio functional evaluation of CA 125 levels as a non invasive diagnostic and prognostic marker in ovarian tumors
Journal Title: International Journal of Medical and Health Research - Year 2019, Vol 5, Issue 5
Abstract
Introduction: CA 125, a 200 kilo-Dalton glycoprotein has been advocated as a prognostic marker in epithelial ovarian cancers and its role as a screening tool, particularly in cases of familial ovarian cancers is being evaluated. Since its development, measurement of serum level of CA125 antigen has become a standard component of routine management of women with advanced ovarian cancer and levels less than 35 U/mL are now accepted as normal. Objective: To assess the diagnostic and prognostic significance of serum CA 125 levels by correlating the pre-operative levels with the histological type, biological behaviour and post-operative levels. Material and methods: 60 cases of ovarian tumors diagnosed between July 2012 to June 2014 were studied to evaluate the association of pre-operative CA 125 levels with age, presenting symptoms, histological grade, presence of necrosis, capsular breach, ascites and extra-ovarian extension. The post-operative CA 125 levels were followed up in cases of malignant ovarian tumors to note its prognostic significance. Results: Epithelial tumors were the most common ovarian tumors and were associated with elevated levels of CA125 which correlated with their grade, presence of necrosis, capsular breach, extra-ovarian extension and ascites. The significant elevation and association of CA125 levels with the known prognostic markers along with the post operative reduction, supports its prognostic significance in cases of epithelial ovarian tumors. Conclusion: CA 125 levels are non invasive, diagnostic and prognostic serum markers in epithelial ovarian tumors.
Authors and Affiliations
Dr. Akriti Kashyap, Dr. Jayashree Krishnamurthy
Keywords
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