Biochemical and Pharmacological Studies of the Condensed Products of α, β Unsaturated Ketones: Docking Studies
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
α, β-Unsaturated ketones commonly known as chalcones are an important class of organic compounds being studied over the years and reported to possess wide spectrum of biological properties such as antibacterial, antifungal, antitubercular, antimalarial, anti-inflammatory, antileishmanial ,anticancer and antioxidant activities. The presence of enone function in the chalcone molecule confers the biological activity, the importance of which is well documented in the literature. In the present work three new series of α, βunsaturated ketones have been synthesized by reacting Acetophenone with 4-carboxyl benzaldehydes by Claisen-Schmidt condensation followed by reaction with amino triazole. The compounds have been characterized by UV, IR, 1H NMR, Mass spectral data and elemental analysis. All the synthesized compounds have been evaluated for their in vitro antibacterial and antioxidant activities. Most of the compounds exhibited antibacterial property at a concentration of 100 μg/ml. All the compounds exhibited antioxidant property with EC50above 500 μg/ml.
Authors and Affiliations
*Manish Rapolu, M. Srinivasamurthy2
Keywords
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