Biochemical Changes and Fatigability in Albino Rats after Oral Administration of Adenosine Triphosphate
Journal Title: International Journal of Biochemistry Research & Review - Year 2016, Vol 10, Issue 1
Abstract
Objective: The study was undertaken to evaluate the biochemical changes and fatigability in albino rats after oral administration of adenosine triphosphate (ATP). Study Design: Animal experimental study. Place of Study: Department of Biochemistry and Pharmacology, S. Nijalingappa Medical College, Navanagar, Bagalkot-587102, Karnataka, India. Methods: Twelve Swiss albino rats of either gender weighing between 200 to 300 gm were taken. Animals were grouped randomly into two groups consisting of 6 rats each. Group –I received distilled water (5 ml/kg body weight) and Group-II ATP orally at the dosage of 60mg/kg body weight for 8 days. On 8th day of experiment, all animals were evaluated for extent of physical fatigue by using exhaustive swimming test. The blood samples were collected and blood sugar, urea, uric acid, hsCRP, total cholesterol and triglyceride were measured. Results: There was a significant (p<0.05) increase in serum uric acid, blood sugar and urea in Group- II as compared to Group- I. Conclusion: Oral administration of ATP may lead to hyperglycaemia, hyperuricemia and dyslipidaemia.
Authors and Affiliations
Sangappa Virupaxappa Kashinakunti, Sheshidhar B annale, R. Manjula, Gurupadappa Shantappa Kallaganada, Kavitha Hiremath
Keywords
Related Articles
- EP ID EP351151
- DOI 10.9734/IJBCRR/2016/23194
- Views 109
- Downloads 0
Defatted Soya Flour Supplementation of Wheat Bread Confers Oxidative, Renal, Hepatic and Cardiovascular Protective Effects in Wistar Rats
Background: The present study was designed to ascertain the effect of supplementation of bread with defatted soy flour on antioxidant, renal, hepatic and cardiovascular status in Wistar rats. Methods: Hard wheat flour w...
Anti-diabetic Effect of the Methanolic Leaf Extract of Axonopus compressus (P. Beauv) in Alloxan Induced Diabetic Rats
Aims: This study is a preliminary step in investigating the anti-diabetic effect of the methanolic extract of the leaf of Axonopus compressus (P. Beauv) in alloxan-induced diabetic rats. Study Design/Methodology: Intrape...
Effect of Different Storage Condition on pH and Vitamin C Content in Some Selected Fruit Juices (Pineapple, Pawpaw and Watermelon)
This research work was carried out to determine the suitable storage condition of fruit juices that will effectively retain their vitamin C content and pH level. Three different samples of fruits were processed into thei...
Study of Insulin Resistance in Polycystic Ovarian Syndrome
Aims: To evaluate Insulin resistance in patients with Polycystic ovarian syndrome (PCOS). To determine if HOMA & G:I can be used as a simple marker to identify PCOS patients at risk for IGT & Type II DM. Study Design: Th...
Diagnosis of Diabetes Mellitus Using Glycated Hemoglobin (A1c): The Nigerian Perspective
Background: Diabetes is an international public health issue. International Expert Committee recommended an alternative diagnostic index testing for diabetes using glycated (A1c). Objective: This study aimed to determin...