Biochemical studies of various risk factors and important minerals in pre-eclamptic patients
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2016, Vol 20, Issue 2
Abstract
Background: The hypertensive disorders of pregnancy are major causes of morbidity and mortality. They may lead to eclamptic conditions causing seizures, comatose conditions and death in hypertensive mothers. It will also lead to disastrous conditions for fetus. The demographic, anthropometric factors like age, parity and obesity are vital in investigating the etiology of the disorder. The changes in biochemical parameters like total protein, albumin contents along with minerals like calcium, phosphorous and magnesium in pregnancy may implicate their possible role in pregnancy-induced hypertension. This study assessed serum mineral levels in women in PE (pre-eclampsia) cases and the control group which were statistically analyzed. Methods: This case–control study was conducted on 90 confirmed pre-eclamptic patients (≥20 weeks gestation), admitted in B. Y. L. Nair Ch. Hospital, Mumbai Central, Mumbai 400008 India, and 90 healthy, age-matched pregnant women (controls), attending OPDs of same department. The demographic, anthropometric, clinical and obstetric data were gathered using an interview-based questionnaire. Venous blood samples were drawn for the estimation of total protein, albumin, calcium, phosphorus and magnesium. Results: The prevalence of PE was highest in the age group of 20 to 30 years. Primigravidae PE cases were more predominant (75.5 %), than multigravidae. Women with hypertensive disorders (PE) had significantly lower serum calcium and magnesium levels than those in the control group (p < 0.0001). The decreased serum total protein content and calcium could be correlated positively with that of magnesium(p < 0.01) in PE cases. These results might offer the guidelines for etiology of the disorder. Conclusion: In this study, age of pregnant woman, BMI along with serum total protein, albumin, calcium and magnesium levels were lower in PE cases than in normal control group.. The supplementation of balanced diet and the minerals during the antenatal period may reduce the problem significantly and the occurrence of hypertensive disorders in pregnancy.
Authors and Affiliations
Uma Shinde, S A Rane, Teja Prabhu, Ching Ling Yi
Keywords
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