Biodegradacja węglowego implantu tchawicy w eksperymencie zwierzęcym
Journal Title: Otolaryngologia Polska - Year 2008, Vol 62, Issue 4
Abstract
Introduction. The radical treatment of tracheal stenosis comprises segmental resection and its reconstruction. The most successful type of reconstruction is the “end to end” technique. In cases with large tracheal defects (over 6 cm) this kind of reconstruction is impossible. From many years the adequate biomaterial is searched for the tracheal reconstruction. Most of the implanted biomaterials undergo biodegradation process. Aim. The aim of the study was to analyze the biodegradation process in carbon fi bers of prosthesis implanted in tracheal defects in animal experiment. Material and methods: We studied the prosthesis implanted in tracheal defects in sheep. The prosthesis were built with composite biomaterial composed of carbon fi bers and polisulfone. The observation period was 1, 2, 3, 4, 6, 8, 24 and 38 weeks. In the morphometric evaluations the breadth, curve width, fullness factor and mean grey level of carbon fibers were assessed. Results. The results showed that carbon fi bers undergo progressively degradation in animal environment. The width gradually decreased. The mean grey level in the fi rst three weeks decreased, but in the next period it increased. Conclusion. The carbon fibers of segmental tracheal prosthesis undergo gradually degradation process in biological environment expressed by decreasing of their dimensions connected with the lost of irregularities and changes of structure density.
Authors and Affiliations
Wojciech Ścierski, Grzegorz Namysłowski, Jerzy Nożyński, Lucyna Turecka, Maciej Misiołek, Eugeniusz Czecior, Grażyna Lisowska, Katarzyna Mrówka-Kata
Keywords
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