Bioevaluation of Sirupellai samoolam herbal formulation for Antiurolithiatic activity
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2013, Vol 2, Issue 2
Abstract
Ayurveda offers vast scope for the successful treatment of urolithiasis. Although most remedies were herbal and proved useful, a systematic scientific evaluation has been reported for only few remedies. Sirupeelai samoolam a herbal formulation was claimed to be useful in the treatment of urinary stones in Ayurvedic literature. Toxicity study confirms that the therapeutic dose of Sirupeelai samoolam was 360mg/kg. The antilithiatic effect of Sirupeelai samoolam was determined on lactose diet + ethylene glycol induced and ammonium chloride + ethylene glycol induced lithiasis in male albino wistar rats. The results obtained after 4 weeks of treatment for the urine estimation of calcium, oxalate, magnesium and protein were significant (p<0.01) in reducing the calculus when compared with the standard drug cystone (750mg/kg) treated animals. Urine calcium oxalate crystals were also reduced in test drug treated and standard treated groups. The histopathological examination of kidney shows normal pattern of the cells, tissues, less damage and no microcrystalline deposition. These observations and results conclude that Sirupeelai samoolam herbal formulation possesses significant antiurolithiatic action and can be used safely for treating urinary calculus.
Authors and Affiliations
A. Tamil Selvan
Keywords
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