BIOLOGICAL ACTIVITIES OF DILLENIA INDICA L. BARK GROWING IN BANGLADESH
Journal Title: Journal of Biological and Scientific Opinion - Year 2013, Vol 1, Issue 2
Abstract
The study was designed to explore possible phytochemical characteristics (group determinant of plant extract) and to investigate the cytotoxic and anthelmintic potential in vitro, using the methanolic extract of bark of Dillenia indica growing in coastal region of Bangladesh. Phytochemical analysis of the crude extract revealed the presence of alkaloid(s), carbohydrate(s), glycoside(s), phenol, tannin, protein(s), gum and mucilages. N-hexane and ethyl acetate soluble fraction of Dillenia indica were screened for cytotoxic activity using brine shrimp lethality bioassay, where vincristine sulphate was used as a positive control. It was noticed that the methanolic extract and its fractions possess potent cytotoxic principles (with LC50 value17.68 mg / ml, 17.68 mg / ml, 15.80 mg / ml and LC90 value 486.61, 287.66, 148.82 μg / ml respectively) compared with positive control vincristine sulphate (LC50 0.631 mg / ml and LC90 value 13.51 mg / ml). The other study was undertaken to evaluate anthelmintic activity where albendazole was used as reference standard. Methanolic extract of barks (25 mg / mL) caused paralysis of the worms at 136 minutes and death at 176.0 minutes while albendazole (positive control) paralyzed and killed the worms at 17.67 minutes and 48 minutes, respectively. The study confirms the mild anthelmintic activity of bark extract of Dillenia indica and therefore suggests the isolation of active principles through bioassay.
Authors and Affiliations
Manjurul Chowdhury, Masudur Rahman Syed , Koushik Sayed , Md. Mizanur Moghal, Jamiuddin Ahmed
Keywords
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- EP ID EP156937
- DOI 10.7897/2321–6328.01202
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