BIOREACTIVE COMPOUNDS AND ANTIOXIDANT PROPERTIES OF METHANOLIC EXTRACT OF FENNEL (FOENICULUM VULGARE MILLER)
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 5
Abstract
Methanolic extract of dried Fennel (Foeniculum vulgare Miller) seeds was analyzed for the presence of bioreactive compounds: ascorbate, riboflavin, tocopherol and polyphenols with potential antioxidant properties. The extract had low ascorbate (197.12+1.82µg), riboflavin (11.97+0.35µg) and tocopherol (280.33+5.67µg/g dry seeds) content. However the extract had high polyphenol content (16.506+0.32mg/g dry seeds). Antioxidant activity of the extract was determined by various mechanisms including DPPH free radical scavenging, metal induced protein and lipid oxidation inhibition and protection of DNA against H2O2 induced damage. Fennel had excellent free radical scavenging activity with IC50 2.1mg dry seed weight. IC50 observed for protection of proteins and lipids against metal ion induced oxidation is 2.1 and 2.5mg dry seed weight respectively. Extract equivalent to 0.5µg seeds is enough to protect DNA against H2O2 induced oxidation. The results suggest that polyphenols are the principal components responsible for high antioxidant potential of methanolic extract of fennel.
Authors and Affiliations
Anita Dua, Ashwani Mittal , Sanjeev Gupta , Ritu Mahajan
Keywords
Related Articles
- EP ID EP114925
- DOI 10.7897/2230-8407.04551
- Views 113
- Downloads 0
WOUND HEALING ACTIVITY OF FLAVONOID FRACTION OF CYNODON DACTYLON IN SWISS ALBINO MICE
The aim of the present study is to evaluate the wound healing activity of flavonoid fraction of Cynodon dactylon in swiss albino mice. The wound healing property of the fraction was studied in excision wound which was in...
IN VITRO ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY OF GINKGO BILOBA BARK EXTRACT
Ginkgo biloba also called as Maidenhair Tree, belongs to the family Ginkgoaceae. In this study, the hydro-Methenolic extract from bark of Ginkgo biloba was screened for their in vitro antimicrobial and antioxidant activi...
CRIMEAN CONGO HEMORRHAGIC FEVER - AN ARTICLE REVIEW
Crimean–Congo hemorrhagic fever (CCHF) caused by negative-sense, single-stranded RNA virus in the genus Nairovirus, family Bunyaviridae. (CCHF) is a tick-borne infectious disease characterized by fever, malaise, headache...
A NOVEL EXPANDABLE CORE OF ELEMENTARY OSMOTIC PUMP: AN EFFECTIVE DEVICE FOR DELIVERY OF POORLY WATER-SOLUBLE DRUGS
The main intention of the present work is to design and evaluate a new Elementary Osmotic Pump (EOP) for efficient delivery of Poorly Water-Soluble Drugs (PWSDs). Drug release from the new system called Expandable EOP (...
IN-VITRO STUDY OF ENTAMOEBA HISTOLYTICA WITH COCONUT JUICE ACT AS AN ANTIAMOEBIC AGENT AT DIFFERENT CONCENTRATION IN NIH MEDIUM
Amoebiasis is a parasitic infection caused by Entamoeba histolytica. It is usually contracted by ingesting water or food contaminated with amoebic cysts. Amoebiasis is an intestinal infection that may or may not be sympt...