Blood donors with HBV core anti-body: a follow-up study
Journal Title: Chinese Journal of Blood Transfusion - Year 2023, Vol 36, Issue 2
Abstract
Objective To evaluate the role of anti-HBc detection in current blood screening strategy by the follow-up of repeated donors with antibody to hepatitis B virus core antigen. Methods Plasma samples were collected randomly from Dalian Blood Center. to test anti-HBc(dual reagents) and anti-HBs via ELISA. The re-donation of eligible donors who were anti-HBc+ and donors reactive to HBV detection were followed up. Results A total of 1 291 plasma samples were collected randomly from May 2017 to March 2018, among which 405 samples(31.4%)were anti-HBc+. The median age of anti-HBc+ group was observed much higher than that of anti-HBc-group (39 vs 31 years old) (P<0.05), but no significant difference was noticed in gender nor the proportion of first-time/repeated blood donors (P>0.05). Among the 405 anti-HBc+ donors, 3 donors were OBI (0.7%), of which one was screened out in second donation. No HBV DNA was detected out in 3 OBI cases. Conclusion Although anti-HBc detection is not suitable in blood screening currently, it is of great value in the assessment of blood donor re-entry for HBV reactive donors in blood screening due to the high anti-HBc prevalence among blood donors.
Authors and Affiliations
Lu ZHOU, Dong WANG, Liang ZANG, Xuelian DENG
Keywords
Related Articles
- EP ID EP738485
- DOI 10.13303/j.cjbt.issn.1004-549x.2023.02.011
- Views 36
- Downloads 0
Characteristics of whole blood donors from 26 blood stations before and after the outbreak of COVID-19:a multicenter study
Objective To analyze the basic characteristics of whole blood donors from blood stations before and after the outbreak of COVID-19. Methods After excluding invalid data, data related to the basic characteristics of whole...
The influence of different detection cycles on the detection results of HBsAg ELISA
[Objective] To analyze the influence of the cycle length of hepatitis B surface antigen (HBsAg) double reagent positive samples collected from voluntary blood donors in Guangzhou on the detection results. [Methods] A tot...
Predictive value of preoperative liver function for perioperative massive blood transfusion in patients undergoing ascending aorta surgery
Objective To explore the predictive value of preoperative liver function for massive blood transfusion (MBT) in patients undergoing ascending aorta surgery. Methods Data from 238 patients undergoing ascending aorta surge...
Study on mitochondrial respiratory function in stored apheresis platelets using real-time energy metabolism detection technology
Objective To explore the optimal parameters for detecting mitochondrial respiratory function (MRF) in apheresis platelets (AP) using real-time energy metabolism detection technology, and to study the change of MRF in AP...
Characterization of platelet-derived extracellular vesicles induced by differential platelet activation pathways
Objective To investigate the effects of platelet activation pathways on the characterization of platelet-derived extracellular vesicles(PEVs). Methods Whole blood from healthy donors was prepared into platelet suspension...