Blood lactate levels and its association with survival outcome in polytrauma patients
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 8, Issue 3
Abstract
Background: Lactate as a marker for tissue hypoperfusion is an established biomarker for morbidity and mortality in patients with sepsis and trauma, but has limited clinical application. Aim of this study is was significant (P<0.001) as compared to 2.8 in survivor. The mean blood lactate level in non to evaluate serial serum lactate levels and its association with mortality of the patients of traumatic injury admitted in trauma centre. Many studies have confirmed relationship between tissue hypoxia and generation of lactate. Reflecting the level of tissue hypoxia, we examined the relationship between blood lactate level and survival rate. Materials and Methods: After the admission of patients of traumatic injury (n=63) in the trauma centre and the establishment of diagnosis, for the evaluation of serial blood lactate levels, we have collected the sample at the time of admission, 12 hours, 24 hours, and 36 hours subsequently. Comparison of two means between survivor and non survivor was performed using unpaired student t test. Results: Out of 63 patients 5 were non survivor and 58 were survivor. The mean blood lactate level in non-survivor was 5.9 at the time of admission, which -survivor was 2.7 after 36 hours, which was also significant (P<0.001) as compared to 0.98 among survivor. Conclusion: Blood lactate level at the time of admission and lactate clearance during the initial hours of admission can be a good predictor of patient’s morbidity and mortality. However, some of our patients with elevated initial lactate values recovered well, probably due to better treatment
Authors and Affiliations
Sunil Sureshbhai Patan, Maulik Nayak, Hitesh P Bariya
Keywords
Related Articles
- EP ID EP442173
- DOI 10.26611/10028232
- Views 172
- Downloads 0
Cord blood bilirubin as a predictor of neonatal hyperbilirubinaemia
Hyperbilirubinaemia is a universal problem as it affects about 60% of full term first week of life. The aim of this study is to evaluate the predictive value of umbilical cord bilirubin in for subsequent hyperbilirubinem...
Role of serum ferroxidase activity of ceruloplasmin in preeclampsia
Aim: To assess the role of ferroxidase activity of ceruloplasmin in women with preeclampsia. Materials and Methods: This study comprised of 40 preeclamptic cases and 40 age matched controls without having preeclampsia. R...
Duration of type 2 diabetes mellitus as a threat indicator for the microalbuminuria; A signal for diabetic nephropathy
Background: Diabetes mellitus is one of the major health problem leading to the long term kidney damage and responsible for 30-40% of all chronic kidney diseases. Aim and Objectives: The study was conducted to find the a...
A study of serum HDL with respect to exercise and vitamin B3 supplementation at tertiary health care centre
Background: Despite numerous therapeutic advances, cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in world wide. Although statins reduce coronary artery disease by approximately 30% Aim...
Serum homocysteine as an independent risk factor in young patients of ischemic stroke
Background: Abnormal Homocysteine (HCY) level appear to contribute to atherosclerosis by direct toxic effect that damages the arterial linings, interfering with the clotting factors and oxidation of LDL. Elevated homocys...