Blood pH and urinary uric acid-creatinine ratio in newborns with asphyxia
Journal Title: Paediatrica Indonesiana - Year 2015, Vol 55, Issue 6
Abstract
Background Asphyxia is one of the leading causes of death in the world. Prematurity (28%), sepsis (26%), and asphyxia (23%) are the most common causes of death in newborns. In Indonesia, the newborn mortality incidence is 82 per 1,000 live births. Blood pH is a routine laboratory examination to diagnose newborn asphyxia, but it is preferrable to avoid such invasive procedures in newborns. An examination of urinary uric acid-creatinine (UA/ Cr) ratio may be useful as an alternative method for diagnosis of asphyxia. Hypoxia causes anaerobic metabolism which will increase the blood acidity, while creatinine will decline as a result of incomplete renal function in newborns. Objective To assess for a possible correlation between blood pH and urinary UA/Cr ratio in newborn asphyxia. MethodsWe conducted an observational, cross-sectional study in Prof. Dr. R. D. Kandou Hospital, Manado, North Sulawesi, from November 2013 to April 2014. Subjects were full term newborns with asphyxia. Blood pH and urinary UA/Cr ratio were compared with Pearson’s correlation test. Data was analyzed with SPSS version 22 software and P values <0.05 were considered to be statistically significant. Results Forty subjects met the inclusion criteria. Their predominant risk factor for asphyxia was fetal distress. Subjects’ mean blood pH was 7.1 (SD 0.1) and mean urinary UA/Cr ratio was 3.7 (SD 1.9). There was a moderate negative correlation between blood pH and urinary UA/Cr ratio (r= -0.55; P<0.001). Conclusion In newborns with asphyxia, lower blood pH is correlated with higher urinary UA/Cr ratio.
Authors and Affiliations
Sally Palit, Rocky Wilar, Ari Runtunuwu, Julius Lolombulan
Keywords
Related Articles
- EP ID EP448581
- DOI 10.14238/pi55.6.2015.352-6
- Views 72
- Downloads 0
Risk factors of soil-transmitted helminth infection among elementary school students
Background Helminth infection remains a health problem, especially in school-aged children. Mass eradication programs with a single dose of anti-helminthic drugs were employed by the local government in some endemic area...
Red cell distribution width and mortality in pediatric sepsis
Background Red cell distribution width (RDW) is a hematological parameter routinely obtained as part of the complete blood count. Recently, RDW has emerged as a potential independent predictor of clinical outcomes in adu...
Prevalence of hepatitis and its correlation with serum ferritin and aminotransferase levels among thalassemia major patients in Indonesia
Background Thalassemia major patients who undergo routine transfusion have an increased risk of acquiring transfusion-transmitted infections (TTI), including hepatitis B and C. These diseases have serious implications an...
Effectiveness of amitriptyline for treating functional dyspepsia in adolescents
Background Functional dyspepsia is common among adolescents. Pain reduces children’s quality of life, psychosocial functioning, and school attendance. Amitriptyline is assumed to be one of the alternative treatments in f...
Impact of malnutrition on febrile neutropenia in children with acute lymphoblastic leukemia during induction phase chemotherapy
Background Acute lymphoblastic leukemia (ALL) is the most common malignancy in children and adolescents. Febrile Neutropenia (FN) is a medical emergency on ALL that often leads to death. Nutrition status assessment on AL...