Bone Graft Substitutes for Bone Defect Regeneration. A Collective Review
Journal Title: International Journal of Dentistry and Oral Science (IJDOS) - Year 2016, Vol 3, Issue 5
Abstract
Objective: The purpose of this review article is to illustrate the current state of development of bone graft substitutes that could be used for bone defect regeneration, as well as to analyze their efficacy for clinical use. Methods: An electronic search of the PubMed, was performed for articles written in English. The focused question was “ideal graft substitute material to choose in clinical practice”?. The searches were limited to articles including: bone graft, bone defect scaffold, bone substitutes, and bone regeneration. An attempt was made to identify clinical studies. During the data collection, the data were extracted from the studies including scaffold material, properties and advantages of bone substitutes, as well as clinical results if the study has been provided clinically. Results: In spite of several acceptable scaffold options available for bone regeneration, these options still need to bridge the gap between research and clinical practice. There is little information available about the cellular basis for bone regeneration in humans. Several problems limit the broad usage of such options, including lack of randomized controlled human studies, and dubious long term results. Conclusion: The studies should be nurtured and monitored by a combination of clinical experience. Future trends may focus on the effective combinations of osteoinductive materials, osteoinductive growth factors and cell-based tissue regeneration tactics using composite carriers. There is no single ideal graft material to choose in clinical practice, therefore researches are ongoing in all relevant fields, to establish modern bone regeneration protocols that may lead to the innovation of ideal graft substitutes.
Authors and Affiliations
Mouetaz Kheirallah
Keywords
Related Articles
- EP ID EP201150
- DOI 10.19070/2377-8075-1600051
- Views 159
- Downloads 0
Dental Involvement in a Child with Triple A Syndrome
Background: Allgrove (or triple A) syndrome is a rare autosomal recessive disorder. The triad consists of three most prominent features of the syndrome. First, Alacrimia (absence of tears). Second, achalasia (oesophageal...
Effect of Post-Polymerization Heat Treatment on a Denture Base Acrylic Resin: Histopathological Analysis in Rats
Aims: This work examined the histological effects, on the rat palatal mucosa, of a denture base acrylic resin, submitted or not to a post-polymerization heat-treatment. Methods: Fifteen adult female Wistar rats, with si...
Cellular Aging promotes CEMP1 Expression in STRO-1 positive PDL cells
We investigated the effects of cellular aging on the expression of cementum and mineralization-specific proteins in human periodontal ligament (PDL) cells, since this is not well studied. Previously, we showed that STRO-...
Evaluation of Plaque Removal Efficacy of a Novel Dye-Containing Toothpaste: A Clinical Trial
Background: Dental plaque contributes to caries and periodontal disease, therefore efficient plaque removal promotes oral health. We hypothesize that individuals brushing with toothpaste containing plaque-indicating dye...
Evaluating Dentine Hypersensitivity Severity in Nigerians using Cumulative Hypersensitivity Index
Aim: This national survey aimed to evaluate the cumulative severity of dentine hypersensitivity (DH) in Nigerians. Method: 1349 urban and rural Nigerian dwellers aged 18-35 years were studied within a six-month period....