Bone-specific Alkaline Phosphatase (BAP) in Primary Hypertension-a pilot study
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 7
Abstract
Background Primary Hypertension is a very common, chronic health problem. It is a significant risk factor for atherosclerosis, cardiovascular diseases, etc.BAPis up-regulated in vascular calcification, CAD, CKD associated cardiovascular events but its association with Primary Hypertention has not been established yet. Objectives To estimate serum BAP level to evaluate cardiovascular risk in patients with Primary Hypertension. Materials and methods: We conducted a pilot studyin 75 patients with Primary Hypertension, in the Department of Biochemistry, VMMC &Safdarjung Hospital, New Delhi, focusing on BAP marker in Primary Hypertension. The study group was divided into cases of 75 patients with Primary Hypertension and controls of 30 healthy individuals without Primary Hypertension. Serum BAP was measured using Sandwich - ELISA method. The mean of serum BAP in cases and controls were 656.36pg/ml (range 63.99-3966.97pg/ml) and 120.32pg/ml(range 20.15-563.97pg/ml) respectively. The cases and controls were compared by using Welch’s t-test. Results: Serum BAP was very significantly raised in cases as compared to controls (p value < 0.0001). Conclusion Our study concludes high serum BAP levels in Primary Hypertension may be related to its pathology. So, these patients should be followed up regularly to assess the risk for cardiovascular events and BAP levels. But, further prospective studies are required to establish this fact.
Authors and Affiliations
Sukanya Gangopadhyay
Keywords
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