Brain changes in Hypothermia: Surface-versus Core-cooling in pigs
Journal Title: Journal of Forensic Science and Research - Year 2017, Vol 1, Issue 2
Abstract
The process of hypothermia in the clinical setting has been practiced for 50 years and is known for its neuroprotective properties. This paper describes histopathological changes either by an ice sludge mimicking accidental hypothermia (S-group n=7) or by endovascular core-cooling (C-group n=7). Focal infiltrates of neutrophilic granulocytes were found in five of seven brains in the S-group and in one of seven brains in the C-group. These granulocytes were found in the arachnoids, in vessels, in vessel walls, and in the cerebral cortex. Fungi, bacteria, lymphocytes or plasma were not found. This experimental study, mimicking accidental hypothermia, reported histopathologic features of aseptic inflammation. To our knowledge, such findings have not been described in hypothermic animals or humans before. We suggest that a local inflammatory response may be triggered in such cases of hypothermia.
Authors and Affiliations
SM Hammersborg, P Husby, I Morild, PK Lilleng
Keywords
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- EP ID EP541653
- DOI 10.29328/journal.jfsr.1001011
- Views 83
- Downloads 0
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