Brain MRI Findings in Children with Acute Lymphoblastic Leukemia
Journal Title: Iranian Journal of Blood and Cancer - Year 2017, Vol 9, Issue 2
Abstract
Background: Patients with leukemia are facing more complications in order to achieve longer survival. We aimed to evaluate the frequency of central nervous system abnormalities (CNS) on MRI of children with acute lymphoblastic leukemia (ALL). Methods: Sixty-six children with diagnosis of ALL aged 2-18 years were recruited. Non-contrast sequences of brain MRI in addition to diffusion weighted imaging of brain were obtained with 1.5 T (Siemens medical system) scanners in their maintenance phase of treatment. The age of onset, type of leukemia, protocol of treatment, and elapsed time from diagnosis were recorded. Chi-square test was used to compare the groups and t-test was used to evaluate the effect of not normally distributed variables. Results: 19 (28.8%) had abnormal CNS findings identified on MRI images including: nonspecific white matter high signal intensity in flair images with normal DWI, white matter ischemia proved on DWI, generalized brain atrophy, isolated mild enlargement of lateral ventricle and extracerebral complications including sinus thrombosis and sinusitis. Brain abnormalities were correlated with leukemia type, chemotherapy protocol and radiotherapy (P=0.006, 0.036, and 0.01, respectively). Conclusion: The wide spectrum of CNS abnormalities that were observed in children with ALL showed correlation with treatment methods and type of leukemia in this study. Combination of radiation therapy and chemotherapy increased CNS complications. Among extracerebral complications, dural sinus thrombosis proved by MRV was seen more frequently in T-cell leukemia patients treated with multiple high doses of the chemotherapy agent “L-asparaginase”. Since some neurological complications of leukemia are treatable, early diagnosis sounds essential.
Authors and Affiliations
Karmella Kamali, Reza Taghavinasab, Sezaneh Haghpanah, Mohammadreza Bordbar, Parsa Kamalipour
Keywords
Related Articles
- EP ID EP234709
- DOI -
- Views 149
- Downloads 0
Studies of Human HbAA Erythrocyte Osmotic Fragility Index of Non-Malarious Blood in the Presence of Five Anti-malarial Drugs
Background: The capacity of human HbAA erythrocytes of non-malarious blood to withstand osmotic stress in the presence of five antimalarial drugs, Chloroquine phosphate, Quinine, FansidarTM, CoartemTM and HalfanTM was st...
Plasma derived versus biotechnological manufactured medicine
This article has no abstract.
Preparation of Plasminogen by Affinity Chromatography
Background: Plasminogen is one of the compounds derived from human plasma. Activation of plasminogen produces plasmin. Plasmin is able to lyse fibrinogen, fibrin, and some other human plasma proteins. The aim of the pres...
Assessment of Psychological Stress Status among Iranian Cancer Patients
Objectives: We aimed to assess psychological stress status among Iranian patients with cancer compared with non-cancer individuals. Patients and Methods: In a case-control study one hundred consecutive cancer patients wh...
How to Care for Implanted Ports
Implantable ports are used for intravenous infusion therapy and play an important role in management of oncology patients. These ports are best suited for patients requiring long-term therapy (>4 weeks). Implanted ports...