Brine Shrimp Cytotoxicity and Anti-Mitotic Activity of Aqueous Root-Bark extract of Securidaca longepedunculata (Polygalaceae
Journal Title: Tropical Journal of Natural Product Research - Year 2018, Vol 2, Issue 3
Abstract
Received 12 July 2017 Revised 13 February 2018 Accepted 21 February 2018 Published online 07 March 2017 Securidaca longepedunculata is a savannah shrub found growing in South-West Nigeria and some other areas in Africa. It has been reported to be used in the treatment of over a hundred ailments. Its root bark is included in several anti-cancer decoctions in Nigeria. Despite its reported use as an anti-cancer plant, there is a dearth of information on the anti-cancer potential of Securidaca longepedunculata in Nigeria. The aim of this research is to determine the cytotoxic and antimitotic activity of aqueous root bark extract of Securidaca longepedunculata. Securidaca longepedunculata aqueous root-bark extract was prepared and used for the study. Cytotoxic activity of S. longepedunculata extract was determined by the brine shrimp toxicity assay and Allium cepa assay was used to assess the anti-mitotic activity. Brine shrimp toxicity assay showed an LC50 of 25.1 µg/mL and the Allium cepa assay revealed that 100 mg/mL extract caused a reduction in mitotic index (MI) which was comparable to that of the standard drug, methotrexate. Securidaca longepedunculata has potential as a cytotoxic agent.
Authors and Affiliations
Ridwan A. Lawal, Sodiq K. Lawal, Omolola S. Odesanmi, Olufemi Isiaq, Ibrahim A. Badmus
Keywords
Related Articles
- EP ID EP489443
- DOI 10.26538/tjnpr/v2i3.1
- Views 96
- Downloads 0
Larvicidal Assessment of Fractions of Aristolochia albida Rhizome on Culex quinquefasciatus
Received 18 April 2018 Revised 03 May 2018 Accepted 07 May 2018 Published online 10 May 2018 Aristolochia albida is a plant, native of Africa that has found various applications including antiparasite and anti-snake ven...
Pharmaceutical and Therapeutic Potential of Miraculin and Miracle Berry
Richadella dulcifica or Synespalum ducificum also known as miracle fruit is a kind of cherry plant, which originates from West Africa. The glycoprotein, miraculin in miracle berry is responsible for its unique function (...
Evaluation of the Anti-Convulsant Activity of Aqueous Leaf Extract of Jatropha curcas (Euphorbiaceae) in Mice
Received 08 October 2018 Revised 26 November 2018 Accepted 26 November 2018 Published online 27 November 2018 The prevalence of epilepsy is particularly high in Latin America and in several African countries notably Lib...
Hypoglycemic, Hepatoprotective and Hypolipidemic Effects of Pleurotus ostreatus in Alloxan-Induced Hyperglycemic Rats
Pleurotus ostreatus (Oyster mushroom) is increasingly being recognized as an important food product with a significant role in human health and nutrition. The present study aims at evaluating the effect of Pleurotus ostr...
Processing and Evaluation of Locally Sourced Kaolin for Pharmaceutical Production
Received 03 July 2018 Revised 05 August 2018 Accepted 09 August 2018 Published online 10 August 2018 Cheaper and readily available natural clay deposits in Nigeria, may serve as good sources of pharmaceutical raw materi...