Broadly Neutralizing Antibodies: The Path towards Universal Vaccines
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 9
Abstract
Active and passive immunization to prevent Influenza virus and Human Immunodeficiency Virus-1 (HIV-1) infection has long been considered a potential treatment modality. Earlier efforts were largely unsuccessful as the antibodies studied neutralized only a narrow spectrum of viral strains. However, recent discovery of a large portfolio of human monoclonal antibodies that are broadly neutralizing across many HIV-1 subtypes and influenza strains has laid the foundation for such immunization strategies with universal vaccines being the ultimate aim. These antibodies target multiple different epitopes on the HIV envelope and influenza glycoprotein, thus neutralizing a broad range of viral variants. In this review, the role of broadly neutralizing antibodies (bNAb) in HIV and Influenza infection will be discussed along with their potential for use in developing structure based universal vaccines.
Authors and Affiliations
Dr Hrishikesh Kashyapa
Keywords
Related Articles
- EP ID EP214364
- DOI -
- Views 69
- Downloads 0
A Cross Sectional Study of Clinical Profile and Cardiac Manifstations in Patients with Primary and Secondary Dengue Fever in A Tertiary Care Hospital
Background: Dengue fever is one the most common mosquito borne viral disease. Cardiac system involvement is one of the atypical manifestations in dengue fever. So this study was conducted to find out cardiac involvement...
Clinical Profile of Tuberculosis in Children: A Prospective Study from Tertiary Care Institute in Sub Himalayan Region
Background: Tuberculosis has the dubious distinction of being the most persistent scourge of humankind. Childhood tuberculosis remains an important cause of morbidity and mortality in the developing countries despite the...
Anatomical Variations of Coeliac Axis and Common Hepatic ArterySystematic Analysis of Multi detector Computed Tomography Images
Purpose: The study was conducted to identify and evaluate the spectrum of anatomical variations of the coeliac axis (CA) and common hepatic artery(CHA) seen in multi detector computed tomography (MDCT) images . Materials...
Congenital Diaphragmatic Hernia- A Case Report
Congenital diaphragmatic hernia (CDH) is an anatomical defect of the diaphragm which allows herniation of abdominal contents into the thoracic cavity, thus causing serious pulmonary and cardiac complications in the neona...
A Study to Evaluate the Role of Dihydrotestosterone in the Pathogenesis of Benign Hyperplasia of Prostate and Prostatic Carcinoma in Patients Attending a Tertiary Care Hospital in Eastern India
Benign hyperplasia of prostate and prostatic carcinoma are two important diseases of aging male with very high incidence rate. Androgens have been implicated in the pathogenesis of both BHP and Ca prostate. Dihydrotestos...