BUOYANT OIL ENTRAPPED CALCIUM PECTINATE GEL BEADS OF FAMOTIDINE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
In the present study, Buoyant oil entrapped calcium pectinate gel beads of Famotidine were prepared by emulsion gelation method. Oil entrapped calcium pectinate gel beads concept was applied to increase the gastric retention time of the drug. Famotidine is a histamine H2 receptor antagonist that inhibits stomach acid production and used in the treatment of peptic ulcer diseases. The obtained beads are capable of floating in the gastric fluid and thus increases the gastric retention time. Drug release was found to uniform and maximum for 24hrs around 80%.The obtained beads were evaluated for size analysis ,morphology, buoyancy test, dissolution profile .This approach is found to be one of the approach for gastro retentive drug delivery and thus increases the drug absorption and activity.
Authors and Affiliations
Annu Kumari , Marina Koland , Girdhari Jha , Shailendra Jha , N Charyulu
Keywords
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- EP ID EP140372
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