But-2-enal. Determination in workplace air
Journal Title: Podstawy i Metody Oceny Środowiska Pracy - Year 2019, Vol 35, Issue 1
Abstract
But-2-enal (crotonaldehyde) is a colourless liquid with an unpleasant suffocating odour. But-2-enal occurs naturally in food. It is mainly used for the production of sorbic acid, a food preservative. But-2-enal is a very toxic, highly irritating and allergenic substance – it is suspected of causing genetic defects. The aim of the study was to develop a method for determination of but-2-enal, which will enable determination of concentrations of this substance in the workplace air in the range from 1/10 to 2 MAC values. The tests were performed using a liquid chromatograph (HPLC) with a diode array detector (DAD), equipped with an Ultra C18 column (250 × 4.6 mm; 5 μm). The method consists in retaining the but-2-enal on a silica gel coated with 2,4-dinitrophenylhydrazine. The sample is extracted with acetonitrile and analyzed by HPLC. Validation of the method was carried out in accordance with the requirements of the European standard EN482. The measuring range of the method is from 0.1 to 2 mg/m3 for a 12 l sample of air. The following validation parameters were obtained: limit of detection: 1.26 ng/ml (0.21 μg/m3), limit of quantification: 3.77 ng/ml (0.63 μg/m3), the overall accuracy of the method: 5.08%, expanded uncertainty: 22%. The developed analytical method enables selective determination of but-2-enal in workplace air at concentrations ranging from 0.1 mg/m3, i.e. from 1/10 of the MAC value in the presence of co-occurring substances. The method is characterized by good precision and accuracy and meets the requirements of the European standard PN-EN 482 for procedures for determination of chemical agents. The developed method of determining but-2-enal has been recorded as an analytical procedure (see Appendix). This article discusses the problems of occupational safety and health, which are covered by health sciences and environmental engineering.<br/><br/>
Authors and Affiliations
Anna Jeżewska, Agnieszka Woźnica
Keywords
Related Articles
- EP ID EP518520
- DOI 10.5604/01.3001.0013.0791
- Views 81
- Downloads 0
2-Metylo-4,6-dinitrofenol. Oznaczanie w powietrzu na stanowiskach pracy
2-Metylo-4,6-dinitrofenol (DNOC) jest żółtym ciałem stałym. Substancja ta działa: owadobójczo, grzybobójczo i chwastobójczo. Obecnie 2-metylo-4,6-dinitrofenol jest stosowany głównie jakoinhibitor polimeryzacji oraz produ...
Dimethyl phthalate – inhalable fraction. Documentation
Dimethyl phthalate (DMP) is a colorless, oily liquid with a faint aromatic odor.It is used in the chemical industry (manufacture of dyes, varnishes) and cosmetics (perfume, bubble bath, etc.) as a plasticizer (e.g., c...
1,1-Dichloroethene. Documentation
1,1-Dichloroethene (vinylidene chloride) is a low temperature boiling liquid with a sweet scent. 1,1-Dichloroethene is used as a chemical intermediate (usually with vinyl chloride) in the production of thermoplastic resi...
Procedure for measuring ultrasonic noise
The need to develop a new procedure for measuring ultrasonic noise was taken from the analysis results of current legislations to ultrasonic noise in a working environment, methods of measuring noise, metrological requir...
Oznaczanie 3,7-dimetylookta-2,6-dienalu w powietrzu na stanowiskach pracy metodą wysokosprawnej chromatografii cieczowej
Na podstawie wyników badań opracowano czułą i selektywną metodę oznaczania stężenia 3,7-dime-tylookta-2,6-dienalu w powietrzu na stanowiskach pracy z zastosowaniem wysokosprawnej chromatografii cieczowej z detektorem di...