Calcidiol level in patients with psoriasis treated with NB-UVB therapy
Journal Title: Postępy Nauk Medycznych - Year 2012, Vol 25, Issue 10
Abstract
<b>Introduction.</b> UVB 311nm phototherapy (NB-UVB) appears to influence the psoriasis significant factor’s genes expression by epidermal syntesis of vitamin D.<br><b>Aim.</b> The aim of this research was to examine whether NB-UVB was able to induce 25(OH)D synthesis in relationship to its initial level and BMI, age, sex, nutrition and behavioral habits.<br><b>Material and methods.</b> Serum 25(OH) D level was measured using RIA-method in 36 patients in T0 before the first dose of radiation, in T1-T3 during the treatment and in T4 and T5 accordingly in 1st and 5th week after the end of phototherapy. The parameters in controls (28 healthy adults) were measured in T0 and T4. Assessment included also: BMI, PASI, skin phototype, questionnaire (sun exposure, nutrition habits).<br><b>Results.</b> Calcidiol level in T0 was higher in patients 33.21 nmg/ml vs. 25.17 ng/ml in controls (p < 0.05). The tendency to lower calcidiol levels among older, women and in patients with a lower PASI index value wasn’t significant (p > 0.05). There was a statistically significant difference in the increase of calcidiol level in patients between T0 and T4 – higher in the group of level < 25 ng/ml. There was an increase of calcidiol level in patients in T4 – 50.16 ng/ml (p < 0.05) and a decrease in controls – 21.37 ng/ml. In T5 calcidiol level in patients was 51.18 ng/ml. 11-45% participants reported consumption of different dairy products. The consumption of fish was declared as at least once a month.<br><b>Conclusions.</b> The initial level of 25(OH)D has an impact on its growth by NB-UVB. The dose of UVB 311 nm received during the irradiation masked seasonal variability of the calcidiol level. There was no effect of BMI or PASI index values, age or gender on the calcidiol level. Nutrition and behavioral habits have an impact on the calcidiol level.
Authors and Affiliations
Magdalena Kolanko, Ligia Brzezińska-Wcisło
Keywords
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