Calcitonin-negative primary neuroendocrine tumor of the thyroid (nonmedullary) in a dog
Journal Title: Open Veterinary Journal - Year 2016, Vol 6, Issue 3
Abstract
The Calcitonin-negative neuroendocrine tumor of the thyroid (CNNET) or "nonmedullary" in humans is a rare tumor that arises primarily in the thyroid gland and may be mistaken for medullary thyroid carcinoma; it is characterized by the immunohistochemical (IHC) expression of neuroendocrine markers and the absence of expression for calcitonin. An Argentine dogo bitch showed a solid, compact thyroid tumor, which was IHC negative for the expression of calcitonin, carcinoembryonic antigen, thyroglobulin and S100 protein, and positive for synaptophysin and cytokeratin AE1-AE3. The Ki-67 proliferation index was low. We cite this case not only because it is the first case report of calcitonin-negative primary neuroendocrine tumor of the thyroid in dogs but also because we want to highlight the diagnostic importance of IHC in this regard.
Authors and Affiliations
E. A. Soler Arias| Hospital Escuela, Unidad de Endocrinología, Area de Clínica Médica de Pequeños Animales, Fac. de Ciencias Veterinarias, UBA, Av. Chorroarín 280, Ciudad Autónoma de Buenos Aires, Argentina, V. A. Castillo| Hospital Escuela, Unidad de Endocrinología, Area de Clínica Médica de Pequeños Animales, Fac. de Ciencias Veterinarias, UBA, Av. Chorroarín 280, Ciudad Autónoma de Buenos Aires, Argentina, M. E. Caneda Aristarain| Alumna de Programa de Investigación. Fac. de Ciencias Veterinarias, UBA, Chorroarín 280, Ciudad Autónoma de Buenos Aires, Argentina
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- EP ID EP9389
- DOI http://dx.doi.org/10.4314/ovj.v6i3.10
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