CALCIUM ENHANCES ANTIINFLAMMATORY ACTIVITY OF ASPIRIN
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
The objective of present study is to evaluate the effects of calcium carbonate and calcium gluconate on acute and subacute inflammation and to study their possible interactions with Aspirin. Calcium carbonate (10 mg/kg) and calcium gluconate (5 mg/kg) were administered individually and also co-administered along with sub therapeutic dose Aspirin (50mg/kg) to study their interaction. The inflammation was induced by carrageenan or a foreign body. Both calcium carbonate and calcium gluconate could not show significant anti-inflammatory activity on their own in acute as well as subacute inflammation models. Aspirin at sub-anti-inflammatory dose (50mg/Kg) when co-administered along with calcium salts produced the significant anti-inflammatory response which was comparable to anti-inflammatory response of aspirin at therapeutic dose (200mg/Kg). Also co-adminostration minimized the gastro-toxicity of aspirin.
Authors and Affiliations
Krishna Choksi , Ashoka Shenoy , A. R. Shabharaya, Minaxi Lala
Keywords
Related Articles
- EP ID EP86409
- DOI -
- Views 194
- Downloads 0
PRELIMINARY PHYTOCHEMICAL SCREENING AND HPLC ANALYSIS OF FLAVONOID FROM METHANOLIC EXTRACT OF LEAVES OF ANNONA SQUAMOSA
The present paper deals with the phytochemical screening of therapeutic importance from Annona squamosa leaves, an important medicinal plant. This study involves the preliminary screening, qualitative thin layer ch...
IN VITRO ANTIOXIDANT ACTIVITY AND TOTAL PHENOLIC CONTENT OF LEAF EXTRACTS OF DALBERGIA SISSOO (ROXB.)
Oxidative stress is the state of imbalance between the level of antioxidant defense system and production of reactive oxygen species. Antioxidants are an ancillary defense against oxidative stress. Natural antioxidants s...
TRANSFEROSOME: THE DRUG LOADED ULTRADEFORMABLE VESICLES FOR TRANSDERMAL DRUG DELIVERY
Now a days, The novel drug delivery system is creating a new interest in development of drug deliveries. Vesicular drug delivery system in also a part of this novel drug delivery system which is designed according to the...
EXPLORATION OF ANTIMICROBIAL POTENTIAL OF METHANOL EXTRACT OF STEMS OF EUPHORBIA NERIIFOLIA
The antimicrobial efficacy of methanol extract of stem of the plant Euphorbia neriifolia (Family: Euphorbiaceae) was evaluated against selected pathogenic bacterial strains (Staphylococcus aureus ATC-2245, Streptococcus...
PHARMACOGNOSTICAL AND PHYTOCHEMICAL INVESTIGATION OF IPOMOEA SEPIARIA KOENIG EX. ROXB. LEAF
Ipomoea sepiaria Koenig ex. Roxb. of the family Convolvulaceae is a perennial climber growing on the bank of streams, rivers, specially over hedges. Traditionally the whole herb is to possess number of therapeutic proper...