Calculation of the Inactivation Cross Section of V79 Cells by Protons in Radiotherapy
Journal Title: Sultan Qaboos University Medical Journal - Year 2007, Vol 7, Issue 3
Abstract
For efficient applications of protons in radiotherapy, detailed knowledge of the corresponding radiobiological mechanism is necessary. Te inactivation cross section is a useful tool to explore the interaction mechanism. Hence, the inactivation cross section for proton irradiation on V79 cells has been calculated using published survival data. Method: Te linear quadratic equation was used to fit the survival curves and the parameter α was used to calculate the cross section. Te cross section σ is plotted as a function of the mean free path λ and the linear energy transfer LET. Results: Te cross section σ-versus-λ curve shows a saturation region between λ≥2 nm and λ≤5 nm. In this region, the inactivation cross section value is about the same as the geometrical area of the DNA segment (≈4 µm2). Such a saturation is also seen in the σ-LET curve. Conclusion: Tis implies that one DNA segment is at a risk upon the traversal of a single proton.
Authors and Affiliations
Faika A Azooz| Department of Physics, College of Education, University of Mosul, Iraq, Tamer J Alkhalidy| Department of Physics, College of Education, University of Mosul, Iraq
Keywords
Related Articles
- EP ID EP13738
- DOI -
- Views 394
- Downloads 13
Pattern of Viral Infections among Infants and Children Admitted to the Paediatric Intensive Care Unit at Sultan Qaboos University Hospital, Oman
Objectives: Te aim of this study was to describe the pattern of viral infections in infants and children admitted to the Paediatric Intensive Care Unit (PICU) at Sultan Qaboos University Hospital (SQUH) in Muscat, Oman...
Caring for Arab Patients A Biopsychosocial Approach
Symptom Sorter
Fused CT/Ga-67 SPECT Images for Detection of Pleural Lymphoma
Attitudes of Students at Sultan Qaboos University towards the Nursing Profession
Objectives: Te aim of this study was to explore the attitudes of Sultan Qaboos University (SQU) students towards the nursing profession. Methods: A sample of 377 students (male = 130; female = 247) were selected from d...