Can chronic failure induce kidney function damage?
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2016, Vol 29, Issue 1
Abstract
DOI: 10.1515/cipms-2016-0007 Accelerated atherosclerosis and increased cardiovascular events have been extensively documented in patients with end stage chronic kidney disease. The aim of our work was to find evidence supporting the theory that chronic heart failure (CHF) induces renal function damage. In our work, lipids, apolipoprotein (apo)AI, NTproBNP, hsCRP, lipid hydroperoxide (LPO) and creatinine levels were determined in patients with CHF. A total of 37 patients who were diagnosed with CHF, as well as 15 healthy persons, were recruited for the study. The patients were placed into 2 groups: patients with NYHA class 2 and NYHA class 3. Using routine laboratory methods, NT-proBNP level, and lipids were measured by way of employing a Cobas Integra analyser, while the concentration of hs-CRP was measured by immunonephelometric methods. Moreover, serum LPO concentration was measured using Cayman’s Assay Kit (LPO). The statistical analysis of the obtained results was performed using the nonparametric Kruskal-Wallis test and Spearman’s correlation analysis. Our work demonstrated that the CHF patients had significantly decrease concentration of HDL cholesterol and apoAI, but increased NT-pro-BNP, hsCRP and LPO levels. In all CHF patients, a significant positive correlation between NTproBNP concentration and creatinine levels, and a significant negative correlation between NTproBNP concentration and apoAI levels, as well as between concentration of creatinine and apoAI levels, was shown. The study results suggest that variation in the concentration of NTproBNP, LPO, hsCRP, apoAI, creatinine, in addition to chronic heart failure progression, gradually accompany the progress of chronic renal failure. What is more, the disorders may lead to the occurrence of cardiovascular events, consequently, to patient death.
Authors and Affiliations
Elzbieta Kimak, Marcin Dziedzic, Aleksandra Kimak, Kamila Stachyra, Andrzej Prystupa, Janusz Solski
Keywords
Related Articles
- EP ID EP101732
- DOI 10.1515/cipms-2016-0007
- Views 108
- Downloads 0
Lipophilicity study of ursodeoxycholic acid
In this work, the researchers determined the chromatographic parameter of the lipophilicity (RMW) of ursodeoxycholic acid under various chromatographic conditions, and using the RP-TLC and RP-HPTLC methods. This chromato...
The anti-HIV, anti-tumor activity of allyl derivatives of 1,2,4-triazole-5-thione, 1,3,4-thiadiazol-2-ylamine and derivatives of bicyclic systems: 1,2,4-triazole[3,4-b]1,3-thiazine, 1,2,4-triazole[3,2-b]1,3-thiazine, thiazolo[2,3-c][1,2,4]triazole
The isomerization of 5H-3,7-diphenyl 6,7-dihydro-1,2,4-triazole[3,4-b] 1,3-thiazine (1) in a sealed tube, in the presence of aqueous Hbr, was carried out, and 7H-2,5-diphenyl-5,6-dihydro 1,2,4-triazole[3,2-b]1,3-thiazine...
The circumstances of diagnosis of occult haemophilia B in a patient with severe maxillofacial injuries
The most common haemostasis disorders are haemophilia A, B and von Willebrand disease. Symptoms of congenital bleeding diathesis can be observed in early childhood, and are easy to recognize. Medical literature describes...
The effect of thyroxin on hepatic redox equilibrium and lipid metabolism in rats treated with doxorubicin
The main side effects of the administration of doxorubicin, a widely used anticancer drug, is the generation of a reactive oxygen species (ROS) in normal cells. As a result, redox disorders and secondary oxidative stress...
Pathophysiological aspects of the pancreas function in rats with monosodium glutamate-induced obesity
Our study demonstrates that neonatal treatment with monosodium glutamate (MSG) leads to the development of visceral obesity in adult rats. In rats’ pancreas of both sexes massive edema and inflammation were found, which...