Can gestational exercise have a positive effect on cognitive functions resulting from brain injury? A rat study
Journal Title: UNKNOWN - Year 2018, Vol 1, Issue 3
Abstract
Aim: The effects of gestational exercise on potential pathological conditions is not known yet. Therefore, in the present study, it was aimed to evaluate the effects of forced running exercise on lipopolysaccharide (LPS)-induced brain damage in pregnant rats. Method: Pregnant females in the experimental group were forced to exercise 30 minutes daily for five days a week. Lipopolysaccharide (LPS)-induced brain injury model was created by administering 500 μg/kg body weight of LPS on gestational days 18 and 19. To evaluate injury histopathologically, brain tissues were fixed at the seventh postnatal day through transcardial perfusion (n=4 pups/group). When the remaining pups reached 30-day of age, Morris water maze test (MWM) was performed to assess memory and learning, open filed (OP) and elevated plus maze (EPM) for testing anxiety, and Porsolt test (PT) for evaluating depression. The groups were defined as brain injury group (BI, n=13) and exercise+brain injury group (E+BI, n=7). Results: The results obtained from MWM test indicated that animals found the platform in a shorter duration and distance at the day five compared to the day three. However, there was no significant difference between the groups. No significant difference was found in OP test regarding the distance traveled, time spent at the margins, movement at the center and the time spent as immobile. However, in the EPM test, the offspring at the BI group displayed higher mobility and increased number of entry to the open arms compared to the E+BI groups (p=0.01). There was no significant difference regarding mobility duration and total distance traveled in the PT test. Conclusion: The results of the EPM test suggests that the gestational exercise can suppress the stress factors in the pregnant females with brain injury leading to the prevention of hyperactivity-induced negative learning behavior.
Authors and Affiliations
Mustafa Dilek, Hayriye Orallar, Gokce Bozat, Nimet Kabakus, Ayhan Cetinkaya, Gamze Dilek, Fatma Karakas, Ali Can Onal, Fahri Yilmaz
Keywords
Related Articles
- EP ID EP489853
- DOI 10.30714/j-ebr.2018339493
- Views 164
- Downloads 0
Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele
Aim: Varicocele is abnormal dilation of testis veins without unclear pathophysiology. Morphological studies showed imbalance between vasoconstrictor and vasodilator mechanisms. We aimed to determine the relationship betw...
Effects of magnesium sulphate on liver ischemia/reperfusion injury in a rat model
Aim: To investigate the protective efficacy of magnesium sulphate in a model of rat liver ischemiareperfusion (I/R) injury. Method: 32 adult female Wistar-Albino rats (250 to 350 g) were used in this experimental study....
Does hemogram biomarkers predict mortality in intensive care population?
Aim: To compare hemogram-mediated inflammatory markers such as mean platelet volume (MPV), red cell distribution width (RDW), platelet distribution width (PDW), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyt...
Surgical treatment with rhomboid excision and Limberg flap technique under spinal anesthesia of 23 youngwith pilonidal sinus disease
Aim:To present the experience of treatment with Limberg flap procedure under spinal anesthesia in 23 young patients with pilonidal sinus disease.Methods:This was a retrospective study of 23 youngpatients who underwent su...
Obesity is associated with lower levels of vitamin D
Aim: In this study we aimed to compare the 25(OH) vitamin D level of obese patients and the serum 25(OH) vitamin D level of healthy individuals who have normal weight; and also to evaluate the relation between 25(OH)...