Can promethazine in combination with sub-analgesic doses of fentanyl offer an alternative to pethidine in pain management? – An experimental study
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2017, Vol 4, Issue 2
Abstract
Introduction: Narcotics like morphine or pethidine are neither widely prescribed, nor readily available as analgesic drugs. Availability of fentanyl is relatively easier, but has tolerability issues and dependence liability. In post-operative setting, fentanyl and promethazine are frequently co-administered. This study aimed at determining the analgesic potential of promethazine in suitable mice models and at studying if combining it with fentanyl could produce analgesia comparable to pethidine, while reducing the dose requirement of fentanyl. Materials and Method: Dose escalation studies were done to determine subanalgesic doses of fentanyl and analgesic potential of promethazine. Subsequently, analgesia by promethazine in combination with sub-analgesic fentanyl was compared to that caused by pethidine. Five groups of mice were evaluated before and after analgesic dosing. Group I served as vehicle control, Group II received pethidine, Group III and IV received combination treatments with promethazine and sub- analgesic doses of fentanyl, Group V received fentanyl. Evaluation of analgesia were done by tail flick analgesiometer and formalin test. Results: Formalin test ratings showed equivalent scores in the pethidine group and fentanyl-promethazine combination groups. Tail-flick latency in the fentanyl-promethazine combination groups was significantly increased in comparison to the pethidine group. When promethazine was combined to sub-analgesic fentanyl, Tail-flick latency was also found to be similar to that of full analgesic dose of fentanyl. Conclusion: The study showed that promethazine had notable analgesic activity in mice. When combined to sub-analgesic doses of fentanyl, promethazine produced better analgesia as compared to pethidine. Combining promethazine to fentanyl reduced the dose requirement of fentanyl without compromising the analgesic efficacy.
Authors and Affiliations
Suvajit Das, Debatri Biswas, Chiranjib Bagchi, Kaushik Mukherjee, Santanu K. Tripathi
Keywords
Related Articles
- EP ID EP295634
- DOI 10.18231/2393-9087.2017.0021
- Views 85
- Downloads 0
Aluminium chloride catalyzed one-pot synthesis of 2-aryl substituted benzimidazoles and their antibacterial activity
2-aryl substituted benzimidazole derivatives were synthesized by using various aromatic aldehydes contains electron releasing as well as electron withdrawing groups, o-phenylenediamine and aluminium chloride as a catalys...
Evaluation of antidepressant effects of rosuvastatin in male albino mice by tail suspension model
Objective: To evaluate the antidepressant activity of Rosuvastatin in male albino mice. Method: Thirty male swiss albino mice were selected for tail suspension model. There were five groups and each group had six animals...
Development and Validation of RP-HPLC Method for Simultaneous Estimation of Paracetamol and Tramadol Hydrochloride
A simple and rapid RP-HPLC method has been developed for the simultaneous estimation of paracetamol and tramadol hydrochloride. The chromatographic analysis was carried out on an Enable C18 column (250×4.6 mm i.d., 5µm)...
Prescription pattern and adverse drug reaction profile of drugs prescribed in dermatology out-patient department at a tertiary care teaching hospital
Introduction: Skin diseases are chronic in nature and they require lifetime treatment. Prescription pattern reflects health professional attitude towards the disease and role of drugs in its treatment. The study of presc...
Precedence of Cognizant Adverse Drug Reactions (ADRs) Reporting in a South Indian Tertiary Care Hospital: A Prospective Study
Objectives: The present study was conducted with the objectives to analyze the ADRs reported to the ADR Monitoring Centre at a tertiary care hospital in Dakshina Kannada district, South India. Methods: Adverse drug react...