Cardiac and Pulmonary Complications in HbE-β Thalassaemia Patients: A Study from West Bengal, Eastern India
Journal Title: Biotechnology Journal International - Year 2016, Vol 14, Issue 4
Abstract
Aims: Hemoglobinopathies including HbE β thalassemia are associated with significant cardiac and pulmonary compromise in affected persons. The aim of this study was to evaluate the cardiac and pulmonary health of transfusion dependent 50 HbE β thalassemia patients of West Bengal. Study Design: 50 transfusion dependent HbE-β thalassaemia patients were selected to evaluate the pulmonary hypertension as it is often associated with anemia. Place and Duration of Study: Sample: Out Patient Department of Thalassaemia Control Unit, Imambara Sadar Hospital, Chinsurah, Hooghly, West Bengal, India between January, 2014 to December, 2015. Methodology: We have evaluated the ECG, Echocardiography and Chest X ray to assess the cardiac function. Chest X ray and Spirometry (FVC, FEV1, FEV1%, PFC) were also monitored to evaluate the pulmonary obstruction. Results: 68% patients showed severe to moderate pulmonary restriction, where as only 10% patients were found to have no significant pulmonary restrictions. The remaining 22% patients showed mild restriction. Other clinical abnormalities found on these HbE-β thalassaemia patents includes palpitation, chest pain, dyspnoea, edema feet and investigation reveals pulmonary arterial hypertension (PAH), volume overload of left heart, pulmonary arterial enlargement, cardiomegaly and LVH strain pattern. Conclusion: In this study, we have found that 68% of all patients showed reportable pulmonary restrictions. Cardiomegaly, volume overload of left heart and LVH strain pattern was found in 26%, 22% and 16% of all patients respectively. Overall, this study will help to get a clear cut and overall idea about the cardiac and pulmonary health of the HbE-β thalassaemia, which ultimately help in the prospective management of the related complications associated with the disease.
Authors and Affiliations
Tridip Chatterjee, Kallol Kumar Bhattacharyya, Annesha Das, Ujjalendu Bikash Mondal
Keywords
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- EP ID EP238016
- DOI 10.9734/BBJ/2016/26529
- Views 132
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