Cardioprotective effect of Nelumbo nucifera on mitochondrial lipid peroxides, enzymes and electrolytes against isoproterenol induced cardiotoxicity in Wistar rats.
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2012, Vol 2, Issue 0
Abstract
Objective: To explore the protective effect of Nelumbo nucifera leaf extract (NNE) on the levels of mitochondrial lipid peroxides, activities of TCA cycle and respiratory chain enzymes and electrolytes in isoproterenol (ISO) induced myocardial infarction (MI) in rats. Methods: Oral pretreatment with NNE to ISO-induced rats for a period of 21 days, then heart mitochondria were isolated for the estimation of various biochemical parameters. Results: Rats induced with ISO showed significant increase in mitochondrial lipid peroxides with subsequent decrease in TCA cycle enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and 毩 -ketoglutarate dehydrogenase (毩 -KGDH) and respiratory chain enzymes like NADH-dehydrogenase and cytochrome-c-oxidase. In addition, the levels of sodium and calcium increased and potassium decreased. Oral pretreatment with NNE to ISOinduced rats for a period of 21 days significantly reverted these biochemical parameters to near normal status. Conclusions: Thus, our study suggests that NNE treatment restore energy status of the mitochondria, thereby maintaining near normal function.
Conservation, genetic characterization, phytochemical and biological investigation of black calla lily: A wild endangered medicinal plant
Scientists continue to search for and conserve plants whose medicinal properties have become crucial in the fight against diseases. Moreover, lessons from folk medicine, indigenous knowledge and Chinese medicine on crude...
Prevalence and antibiotic susceptibility pattern of floroquinolone resistant S h i g e l l a species isolated from infants stool in Gulbarga district, Karnataka, India
Objective: To resolve the incidence rate of Shigella species and emergence of multiple drug resistance to cephalosporins and fluoroquinolones generation drugs in Gulbarga district and nearby area is a matter of concern f...
First molecular characterization of C r y p t o s p o r i d i u m from three different points of two main rivers in Kuantan, Malaysia using 18S rRNA gene nested PCR
Objective: To identify 18S ribosomal RNA (18S rRNA) partial sequences from three different points, namely, downstream, midstream and upstream of two major rivers in Kuantan, Pahang, Malaysia. Methods: In this study, six...
Surveillance for low pathogenic avian inflenza viruses in live-bird markets in Oyo and Ogun States, Nigeria
Objective: To conduct sero-epidemiological and virological surveillance for lowly pathogenic avian influenza virus (LPAIV) in apparently healthy birds slaughtered at live-bird markets (LBMs) in Southwestern Nigeria. Meth...
Modeling of dengue occurrences early warning involving temperature and rainfall factors
Objective: To understand dengue transmission process and its vector dynamics and to develop early warning model of dengue occurrences based on mosquito population and host-vector threshold values considering temperature...