CARDIOPROTECTIVE EFFECTS OF ETHANOLIC LEAF EXTRACT OF IPOMOEA BATATAS ON DOXORUBICIN INDUCED CARDIOTOXICITY IN RATS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2
Abstract
 Objective: This study was aimed to investigate the protective effects of ethanolic leaf extract of Ipomoea batatas (EEIB) on doxorubicin (DOX)induced cardiotoxicity using Albino Wistar rats by monitoring the enzymatic, non-enzymatic antioxidant levels, serum enzyme levels, microscopicalexaminations and the study in electrocardiography (ECG) alterations.Methods: The rats were treated with EEIB (300, 600, 900 mg/kg body weight, n=6) and vitamin C (50 mg/kg) orally for 10 days and the rats werealso treated with DOX 15 mg/kg on 7th day. On the 11th day, the rats were treated with anaesthetized with anesthetic ether, ECG and the levels ofbiochemical and histological observations of the heart tissues were performed.Results: The levels of cardiac markers like creatinine kinase (CK-MB), CK, lactate dehydrogenase and lipid peroxides were significantly decreasedin the extract (600, 900 mg/kg) and ascorbic acid pretreated rats when compared to DOX with significance p<0.001. In heart superoxide dismutase,catalase, tissue protein and glutathione levels were significantly increased in the extract (600, 900 mg/kg) and ascorbic acid pretreated rats whencompared to DOX with significance of p<0.001. The heart weight and electrographic alterations were gradually recovered by the extract in a dosedependentmanner. There was no significant recovery of the above-mentioned parameters with an extract dose of 300 mg/kg.Conclusion: The study revealed that the extract and vitamin C have a dose-dependent potential to prevent oxidative damage/free radical damageinduced by DOX in heart.Keywords: Doxorubicin, Vitamin C, Ipomoea batatas, Serum enzymes, Antioxidant enzymes.Â
Authors and Affiliations
Shiva Shanker Rai, Balakrishna Somashekar, Shivalinge Gowda K. p
Keywords
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