Cardiospecific deletion of β-catenin gene associated with an activity violation of signaling cascades involved in the development of myocardial hypertrophy
Journal Title: Вісник Українського товариства генетиків і селекціонерів - Year 2017, Vol 15, Issue 2
Abstract
The aim of our study was to investigate the molecular mechanisms of hypertrophy response under cardiospecific β-catenin haploinsufficiency condition. Materials and methods. Studies were done with β-catenin condtional knockout mice (β-catflox/flox) and α-MHC-Cre-transgenic mice. To induce hypertrophy we used swimming test during 6 weeks. Using western-blot, we have analyzed the level of studied proteins. Results. It has been shown that the β-catenin haploinsufficiency is associated with increased signaling activity of MAPK, PI3-kinase-mTOR-dependent signaling cascades in both: with prolonged physical activity and without it. However, even with an increased activity of this signalling, β-catenin haploinsufficient mice expressed weaker hypertrophic response. Conclusions. The transcriptional activity of β-catenin is necessary for the proper interaction of signaling cascades during heart maturation and adaptation to stress.Keywords: β-catenin, hypertrophy, Wnt-signalling, MAPK signalling, PI3-kinase-mTOR-dependent cascade, РКА-signalling, myocardium.
Authors and Affiliations
O. L. Palchevska, V. V. Balatskyi, L. L. Macewicz, O. O. Piven
Keywords
Related Articles
- EP ID EP613342
- DOI 10.7124/visnyk.utgis.15.2.877
- Views 79
- Downloads 0
Ярослав Борисович Блюм (до 60-річчя від дня народження)
Віталій Арнольдович Кордюм (до 85-річчя від дня народження)
Genetic-physiological basis of legume crops resistance to drought stress
Goal. Identify the effective criteria for drought tolerances of leguminous crops, based on their basis evaluate the recommendation for cultivating soybean cultivars and discuss the mechanisms of resistance on the organis...
Academician of the NAS of Ukraine Yuri Yurievich Gleba (to the 70th anniversary)
Professor N. M. Drobyk — a talented scientist, teacher and organizer of science (to the 50th anniversary)
Висвітлено основні віхи життєвого шляху і найголовніші наукові здобутки та досягнення у науковій, педагогічній і науково-організаційній роботі віце-президента Українського товариства генетиків і селекціонерів ім. М. І. В...