Cardiovascular and Antioxidant Effects of the Methanol Extract From the Stem Bark of Erythrina Senegalensis DC (Fabaceae)
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2013, Vol 3, Issue 4
Abstract
The present study was undertaken to investigate the cardiovascular and the in vitro antioxidant activities of the methanol extract of the stem bark of Erythrina senegalensis (EMES), a plant used traditionally in Cameroon against arterial hypertension. The cardiovascular effects of EMES (11-44 mg/kg) were evaluated in vivo on normotensive rat arterial blood pressure and on rabbit’s electrocardiogram (5.5- 55 mg/kg) while the in vitro study (10-10 - 1 mg/ml) on myocardial contractile performance was evaluated on rat isolated heart. The antioxidant activities of EMES (1-1000 μg/ml) were investigated on 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide (H2O2)-induced haemolysis, nitric oxide (NO) production, as well as its reducing power. The intravenous injection of EMES provoked in anaesthetized normotensive rats, a dose dependent immediate reduction in arterial hypertension. The mean arterial blood pressure dropped by 11.29, 19.84 and 24.42 % at respective doses of 11, 22 and 44 mg/kg. When administered intravenously in rabbit EMES significantly reduced the heart rate, amplitudes of P wave and QRS complex while significantly increasing the duration of the QT interval. EMES exhibited a concentration dependent reducing power, antiradical activity on DPPH (EC50 of 46.9 μg/ml) and a significant (p<0.001) antioxidant effect on H2O2-induced haemolysis. EMES also substantially increase NO production. In conclusion, EMES exert immediate hypotensive effect which might be attributed to its negative inotropic and chronotropic effects. Its in vitro antioxidant activities could be beneficial for the treatment of cardiovascular ailments.
Authors and Affiliations
A. D. Atsamo , S. A. Néné-Bi , K. L. Kouakou , K. C. Fofie , P. Nyadjeu , J. Y. Datté , A. Kamanyi , T. B. Nguelefack
Keywords
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