CARDIOVASCULAR RHYTHMIC PACEMAKING ACTIVITIES OF SELECTED BOTANICAL EXTRACTS ON CARDIAC CHANNELOPATHY TACHYCARDIA ARRHYTHMIAS-INDUCED MYOGENICHEART USING IN VIVO MODEL OF FRESHWATER CRUSTACEAN DAPHNIA MAGNA (WATER FLEA).
Journal Title: International Journal of Advanced Research (IJAR) - Year 2019, Vol 7, Issue 2
Abstract
Cardiac rhythmicity leads to sudden cardiac death which poses a unique challenge to lessen heart diseases that can cause sudden cardiac death in older and younger individuals. In vivo cardiovascular rhythmic pacemaking activities of selected botanical extracts on cardiac channelopathy tachycardia arrhythmias-induced myogenic heart was employed using in vivo model of freshwater crustacean daphnia magna (Water flea). Daphnia magna were cultured, maintained photoperiod at 16 hours light and 8 hours darkness before using as test specimens in the experimentation. Selected botanical extracts were used as treatment concentrations (10%, 20%, 30%) for cardiotoxicity and cardio activity (heartbeats/min). A total of 250 test specimens or daphnids/neonates were collected and used in cardiotoxicity assessment of the selected botanical extracts after a 12 hr time exposure to each treatment concentration solutions (10%, 20%, 30%). Tachycardia arrhythmia was induced by a caffeine dilute solution concentration (30%) in the bathing medium. Three hundred daphnids/neonates were used as test specimens in measuring the arrhythmias-induced myogenic heart of daphnids/neonates in ten replicates determination. Results showed that the selected botanicals are dose-dependent which means that the higher dosage the greater effect to the heartbeat rates. It was revealed that the losses of DPPH absorbance at 540 nm of the selected botanical extracts were in agreement with its anti-tachycardia arrhythmia effect to the heart rate of Daphnia magna. Results showed that the increase in treatment concentrations and time exposure had positive response against cardiac tachycardia arrhythmias-induced myogenic heart of Daphnia magna which behaves similarly to the heartrate of humans.
Authors and Affiliations
Lorie E. Malaluan, Charmaine Aubrey G. Galindez.
Keywords
Related Articles
- EP ID EP484395
- DOI 10.21474/IJAR01/8546
- Views 58
- Downloads 0
CULTIVATION OF WILD PLEUROTUS SPECIES ON AGRICULTURAL SUBSTRATES AND EVALUATION OF THEIR NUTRITIONAL PROPERTIES.
Three wild isolates of Pleurotus were collected from different parts of north western Himalayas. Based on the morphological and cultural traits isolates were identified as i.eP.djamore ,P.ostreatus and Pleurotusflorida ....
THE REQUIREMENTS FOR TRANSFER PRICING DOCUMENTATION WITHIN THE FRAME OF BEPS ACTION PLANS.
As one of the pioneers and major contributors to the Base Erosion and Profit Shifting (BEPS) initiative of the Organisation for Economic Co-operation and Development (OECD) and G-20 countries, on 16 March 2016, the Reven...
WHITEFLY DIVERSITY (HEMIPTERA: ALEYRODIDAE) AND ITS PARASITOIDS IN LOWLAND IN WEST SUMATERA.
Whitefly is an important pest in various fruit plants. This study aimed to study the diversity of whitefly in fruit plants in the lowlands of West Sumatra. Fruit plants samplings were guava, sweet orange and lime. Sampli...
A CASE REPORT OF BERNARD-SOULIER SYNDROME IN DIFFERENTIAL DIAGNOSIS OF IMMUNE THROMBOCYTOPENIC PURPURA
Bernard-Soulier Syndrome (BSS)is a rare hereditary disorder.Platelets in patients with BSS are unable to adhere, leading to an increased bleeding tendency. BSS cases are often misdiagnosed as idiopathic thrombocytopenic...
STUDY OF EYE ANATOMY (NETRA SHARIR) IN COMPUTER VISION SYNDROME.
Background:Computer Vision Syndrome (CVS) is a name given to the collection of symptoms which occur as a result of prolonged exposure to computer screens. In this paper we studywhether CVS causes any anatomical changes i...