Carotid artery intimal media thickness and ankle brachial index as predictors for atherosclerosis in pre-diabetic patients
Journal Title: International Journal of Medical Science and Public Health - Year 2017, Vol 6, Issue 10
Abstract
Background: Atherosclerosis still remains as the major cause of death and premature disability in developed societies. Insulin resistance is a central pathogenesis feature of prediabetes, the incidence of which is rising substantially. The principal cause of end organ damage in prediabetes is premature cardiovascular atherosclerosis. Objectives: To assess the atherosclerosis in prediabetes. Materials and Methods: Patients who were nondiabetic of age group between 18 and 50 years were screened for fasting blood sugar, post-prandial blood sugar, hemoglobin A1c, after obtaining informed consent and were divided to study group and control group according to inclusion criteria. Results: In this study, abnormal carotid intimal media thickness (CIMT) was observed in 7 (17.1%), out of 41 pre-diabetic patients. This difference in CIMT findings between two groups was statistically significant. Prediabetics are at 8 times higher risk of developing abnormal CIMT than nondiabetics. Abnormal CIMT was associated with greater body mass index, waist-hip ratio, low high-density lipoprotein, high triglycerides, and abnormal ABI. Conclusion: Prediabetes was associated with higher risk of developing subclinical atherosclerosis when compared to non-diabetic patients. Lifestyle modification should be adopted to prevent the conversion of prediabetes into Type 2 diabetes mellitus and thus prevention of its complication.
Authors and Affiliations
Surya Prasad R, Vidyasagar C R, Anil Kumar Sakalecha, Prabhakar K, Prasanna Kumar
Keywords
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- EP ID EP332711
- DOI 10.5455/ijmsph.2017.0824506092017
- Views 95
- Downloads 0
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