Carotid Artery Stenosis and Homocysteine in Ischemic Stroke: A case-control study
Journal Title: Journal of Neurological Sciences-Turkish - Year 2005, Vol 22, Issue 4
Abstract
Background: Hyperhomocysteinemia, has been identified as being associated with vascular disease, including cerebrovascular disease in general. The aim of our study is based on the evaluation of the correlation between the elevated plasma homocysteine levels and the lipid profile and carotid artery stenosis in the acute stroke phase. Methods and Materials: 48 consecutive patients with ischemic stroke were analyzed by homocysteine, vit B12, folic acid, total cholesterol, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol, triglyceride and doppler ultrasonography and vascular risk factors were recorded. Thirty eight control subjects of same ages were compared with the patient group. Results: The homocysteine levels in the patient group were found to be significantly high compared to the control subjects; and negative correlation has been determined between homocysteine and vitamin B12. The correlation between the elevated homocysteine levels and the serum lipid levels has not been considered as significant; however, it was found to be associated with intima-media thickness in the extracranial carotid arteries and severe (50-70%) carotid artery stenosis. Conclusion: The finding of lightly or moderately elevated homocysteine levels in the acute phase of the patients with ischemic stroke has been determined as vascular risk factor in our study. Significant correlation has been found between homocysteine concentration and intima-media thickness and carotid artery stenosis.
Authors and Affiliations
Goksel SOMAY, Tulay ALISKAN, Nuri ERENOGLU
Keywords
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