Caveolae and Caveolin: Potential Targets for Cardioprotection
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 8
Abstract
Caveolae are sphingolipid and cholesterol rich micro-domains of the plasma membrane that coordinate and regulate varieties of signaling processes. Caveolae present in essentially all cell types of the cardiovascular system, including endothelial cells, smooth muscle cells, macrophages, cardiac myocytes, and fibroblasts. Numerous functions have been ascribed to this omega-shaped sphingolipid and cholesterol rich micro-domains. Caveolae are receiving increasing attention as cellular organelles contributing to the pathogenesis of several structural and functional processes including cardiac hypertrophy and heart failure. At present, very little is known about the role of caveolae in cardiac function and diseases, although recent studies with caveolin knock-out mouse have shown that caveolae and caveolins play a pivotal role in various human pathobiological conditions. This review will discuss the possible role of caveolae in cardiac health and disease.
Authors and Affiliations
Dr Manika Das
Keywords
Related Articles
- EP ID EP374369
- DOI -
- Views 82
- Downloads 0
Implementation Levels of a Life-Skill Based School Health Program in a Caribbean Country
Background: The purpose of this study is to determine the levels of implementation of a School health program implemented in schools in a Caribbean Island State. The Health and Family Life Education (HFLE) program was de...
Factors Associated With Utilisation of Antenatal Care Services by Pregnant Women Aged Between 18 and 49 Years in Masvingo Province
Objectives: The study sought to identify factors associated with utilization of antenatal care (ANC) services by women aged between 18-49 years in Masvingo Province Methods: An analytical cross sectional study guided by...
A Study on the Knowledge, Attitude and Demand of Labour Pain Relief Techniques among Antenatal Women in a Selected Hospital at Mangaluru with a View to Prepare a Concept Map
Background: Labour pain is one of the most severe pain experienced by women and it is amenable to treatment. Most of the Indian parturient still suffer from the agony of labour pains due to lack of awareness, lack of ava...
Patients’ Satisfaction with Destructive Eye Surgery in Ophthalmic Plastic Clinic in a Tertiary Institution
Purpose: To determine the rate of eye removal with their indications in a tertiary eye care centre and to assess patients’ satisfaction with the procedure. Materials and Methods: The study was carried out between January...
Effect of a Voice Training Program on Acoustic Voice Parameters in Secondary School Teachers
Teachers are known to be vulnerable to voice disorders because of the excessive use of their voice for professional purposes. This study aimed to investigate the effects of a vocal training program on select acoustic voi...