CD4+T- Lymphocytes And Alanine Aminotransferases of HIV Positive Patients Co-Infected With Hepatitis B Virus As Seen At The University Of Abuja Teaching Hospital: A 10 Year Retrospective Study.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
Introduction: Hepatitis B virus infection and HIV infection are both endemic in Sub-Saharan Africa and both have similar routes of transmission. Our aim was to determine the prevalence of HIV/HBV co-infection at the University of Abuja Teaching Hospital, Gwagwalada, and also to study the profile of CD4+ lymphocytes and alanine aminotransferase of patients with HIV/HBV co-infection compared to that of patients with HIV infection alone. Method: The medical records of 1043 HIV patients enrolled into care at the University of Abuja Teaching Hospital from January 2005 to January 2015 were reviewed. Results: Of the 1043 HIV patients that were studied, 116 had a positive HBsAg test, giving an HIV/HBV coinfection prevalence of 11.1%. The gender-specific prevalence rates of co-infection for males and females were 15% and 9.1% respectively (p=0.004).Thoughthe mean serum ALT level among those co-infected was higher (39.0 International Units (IU)/L) compared to those with HIV infection alone (34.5IU/L), this difference was not statistically significant (p=0.05). The mean CD4+ cell count was significantly lower among those withHIV/HBV co-infection (341.96cells/ml) compared to those with HIV infection alone (410.68cells/ml)[p=0.007]. Conclusion: HIV/HBV co-infection is common in our setting; we found a prevalence rate of co-infection of 11.1%. More men than women were co-infected. CD4+ cell count was lower among those with co-infection compared to those with HIV infection alone.
Authors and Affiliations
Vivian Kwaghe, Abdulkareem Lukman
Keywords
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- EP ID EP552593
- DOI 10.9790/0853-1803014346.
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