Cellular Atypia as a Risk Factor for Persistant Trophoblastic Disease: Prospective Cohort Study
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 6
Abstract
Introduction: Gestational trophoblastic tumours have varying behavior from being locally invasive to metastatic. It would be useful if there is an effective prognosticating method especially in low resource settings. This study was an attempt to identify such a prognosticator. Aim: To look for the presence of atypical cells in the histopathology of vesicular mole, the βhCG level four week after evacuation and look for any association with persistent trophoblastic disease (PTD) Material and Methods: It was hospital based prospective cohort study conducted in a tertiary care hospital. 95 cases of vesicular mole were studied .The patients had a pre evacuation βhCG done and underwent suction curettage. The products were sent for histopathologic examination and apart from identifying the grade of proliferation they were specifically examined for presence of atypical cells. The βhCG levels four weeks after evacuation was checked. Results: On looking at the distribution of atypical cells with βhCG four weeks after evacuation, it is seen that of the 90.6% of the patients with cellular atypia had abnormal levels of status four weeks βhCG levels. With regards to the distribution of atypical cells with the time needed to reach baseline βhCG ,out of the 32 patients with atypical cells 23 (71.9%) had an abnormal βhCG fall. Conclusion: Looking for the presence of atypical cells in the histopathology of vesicular mole can prognosticate the nature of regression of the tumor and help in classifying it as high risk and low risk.
Authors and Affiliations
Dr Uma Thankam
Keywords
Related Articles
- EP ID EP522371
- DOI -
- Views 70
- Downloads 0
Morbidity Pattern of Non-Communicable Diseases among Pregnant Women Attending A Tertiary Care Hospital in Kashmir Valley, India
Background: The study was conducted with the aim to observe the pattern of non-communicable diseases, mainly hypertension, diabetes mellitus, hypothyroidism and anemia in antenatal cases who attended outpatient departmen...
Histopathological Study of Skin Biopsies from Clinically Diagnosed Leprosy Patients – 1 yr Institutional Study
Leprosy is caused by M. leprae and predominantly affects the skin and peripheral nerves. The disease is endemic in many tropical and subtropical countries Materials and Methods: 38 skin biopsies from patients clinically...
Seasonality and First Ever Ischemic Stroke, In Sohag University Hospital, Sohag, Egypt
Introduction: The effect of Seasonality on stroke has been reported in several regions worldwide. Nevertheless, there is inadequate data related to these phenomena in other areas. The aim of the present study was to inve...
Cell Cycle Proteins (NFkB, P53, P21, P27) Determination in Patients Samples with Hodgkin's Lymphoma
Background: p53 tumor suppressor pathway and other cell cycle regulatory proteins has been suggested as a candidate pathogenic mechanism in Hodgkin's lymphoma ( HL). Aim: evaluating the frequency of of expression of the...
GPU Based Rician Noise Removal in MR Images Using Fast Gradient Projection Algorithm
This paper presents a combined Fast Gradient Projection Method with Gabor filter technique for removing the Rician noise present in MR images using general purpose Graphics Processing Units (GPUs) and MATLAB. In this wor...