Central Nervous System Depressant Effect of Senna occidentalis Linn. (Fabaceae) Leaf Extract in Mice
Journal Title: Journal of Pharmaceutical Research International - Year 2017, Vol 18, Issue 5
Abstract
Senna occidentalis has been used in traditional medicine in Nigeria for managing various ailments in traditional medicine. This study was aimed at evaluating the central nervous system depressant effect of ethanol leaf extract of Senna occidentalis in mice. Thirty mice of either sex were taken and divided into five groups of six animals each. First group was considered as negative control in diazepam-induced sleeping time (normal saline + diazepam), second, third, fourth and fifth as test groups (with 20 mg/kg, 40 mg/kg, 80 mg/kg and 100 mg/kg doses of the extract + diazepam). All the drugs were administered intraperitoneal (i.p). The extract showed significant decrease in the onset of sleep at doses of 20 mg/kg, 40 mg/kg and 80 mg/kg (p<0.05; One-way ANOVA). The number of head dips have significantly decreased at p<0.05 for all the graded doses of the extract. Beam walking test for motor deficits, showed significant increase in the number of foot slips at the same graded doses at p<0.05 with no significant difference in the time taken to complete the task. The study showed that leaf ethanol extract of Senna occidentalis possess CNS depressant effect, and serve as a good sedative as such, can save patients from many doses of anesthetic medication usually administered during surgery in conventional medicine when used.
Authors and Affiliations
A. Ukwubile Cletus, Musa Y. Dibal, Troy S. Malgwi, M. Ibrahim Hadiza, Y. Abdulrahman Adama
Keywords
Related Articles
- EP ID EP313033
- DOI 10.9734/JPRI/2017/25432
- Views 121
- Downloads 0
Molecular Characterization Using gtf Gene Detection and Medium Optimization of Beta-D-Glucan Production from Pediococcus parvulus F1030 Isolated from Local Egyptian Boza
Background: Lactic acid bacteria (LAB) have great benefits which can improve the nutritional value of food, reduces some infections, immune modulator effect, curbs some types of cancer and restricts glucose level of seru...
A Review on Huntington’s Disease
Huntington’s Disease (HD) is a progressive neurodegenerative disorder that gradually declines cognitive skills, impair memory and normal movements of affected individuals. This disease affects cerebral cortex and basal g...
Adverse Drug Reaction Reports in an Antiretroviral Treatment Centre in Jos, North Central Nigeria
Background: Reports of adverse drug reactions (ADR) in the era of increasing uptake of antiretroviral drugs particularly in Sub Saharan Africa and especially in Nigeria have been on the rise. Aim: We set out to collate...
X-ray Crystal Structure of COX-2 Enzyme as a Tool to Predict Active Sites of Bitter Taste Receptors
This commentary discusses a novel approach to be used in the design of active sites of bitter taste receptors, especially TAS2R14, by using the X-ray crystal structure of the enzyme COX-2 and chemical structures of commo...
Pre-clinical Evaluation of the Hypotensive and Anti Atherogenic Activity of Hydroethanolic Extract of Eribroma oblongum (Malvaceae) Stem Bark on Wistar Rats Models
Aims: The stem bark of Eribroma oblongum (Malvaceae) is used in traditional Cameroonian medicine to treat various metabolic illnesses including the management of hypertension without scientific evidence to how relief is...