Cerebrospinal Fluid Lactate Concentration to Differentiate Bacterial from Viral Meningitis in Children
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 15, Issue 5
Abstract
Objective: To define an optimal CSF lactate concentration that can be called significant for the differentiation bacterial meningitis from viral meningitis in children. Methods: Children with clinical findings compatible with meningitis were studied. CSF lactate and other conventional CSF parameters were recorded. We determined the optimum cutoff point for CSF lactate using receiver-operator curve (ROC) analysis. Results: We identified 54 had bacterial meningitis. Children with bacterial meningitis had а higher median CSF lactate level [6.5 mmol/l, interquartile range (IQR) 2.3-10.7 mmol/l bacterial meningitis vs. 2.1 mmol/l, IQR 1.3-2.9 mmol/l viral meningitis]. А CSF lactate cutoff point of 3.0 mmol/l had а sensitivity of 87.0% (95% CI 66.4 - 97.2%), а specificity of 87.1% (95% CI 70.2 - 96.4%) for bacterial meningitis. The CSF lactate concentration is а better marker compared to other conventional markers including CSF glucose and CSF total number of leukocytes.Conclusion: In combination with а validated meningitis clinical prediction rule, the CSF lactate level can be used to distinguish between bacterial and viral meningitis in children.
Authors and Affiliations
Ton Nu van Anh, Nguyen Huu Son, Mai Thi Hien Uyen, Nguyen Thi Hong Duc, Tran Vinh Phu
Keywords
Related Articles
- EP ID EP587591
- DOI 10.26717/BJSTR.2019.15.002769
- Views 170
- Downloads 0
Is there any Synchronization between Blood in Urine and Dandruff?
The utmost intention of this article was to assess if there is a connection between blood in urine and dandruff. Presence of 5 or more red blood cells in urine is known as hematuria. Macroscopic or gross hematuria has vi...
Goldenhar syndrome: An oculo-auriculo-mandible syndrome was reported
In A 2-month-old girl with suffer from eye-facial problems was referred to our clinic. The baby was full-term [1,2] delivery without complications. She had limbal dermoid of left eye with 3mm diameter and both eyes with...
Multiple Sclerosis and the Pathogenicity of Mir-155
Multiple sclerosis (MS) is one of the complex diseases. Genetics, environmental and emotional factors have shown to play essential roles in evoking the disease pathology. More interestingly, epigenetic factors were estab...
Trauma of the Pelvic Ring: Epidemiological and Etiopathogenic Aspects
The injuries of the pelvic ring are the set of mechanical lesions affecting the pelvic girdle formed by the 2 iliac bones, the sacrum and the coccyx. The acetabular cavity is an anatomical region belonging to the pelvis,...
Electroacupuncture Against Ethanol-Induced Gastric Ulcer in Rats: Effects on Gastric Contractility and in the Levels of TNF-α
Objective: To correlate the effects of the Electroacupuncture (EA) with the levels of TNF-α and the gastric contractility in both ulcerated and non-ulcerated control rats. Methods: Before the experiments, a magnetic mark...