CHANGES IN THE SURFACE OF DYING CELLS AND IM MUNE RESPONSE
Journal Title: Праці Наукового товариства ім. Шевченка - Year 2015, Vol 43, Issue 2
Abstract
Surface o f dying cells is undergoing changes, needed for their effective clearance by phagocytes. Ability o f dying cells to indicate to their microenvironment the necessity o f self-elimination is a key feature of apoptosis and is preventing tissue damage and inflammation, attributable to necrosis. Deficiency o f dying cell engulfment leads to the accumulation o f immunogenic components of dying cells and to the formation of autoantibodies and subsequent development of autoimmune disorders. Current review summarizes latest data regarding changes o f the surface o f dying cells and their influence o f neighboring cells, particularly on cells of immune system. It briefly covers the process of cell death and changes on dying cell surface; processes o f dying cell elimination, including signals for attracting phagocytes ("find me” signals), signals for recognition of apoptotic cells ("eat me” signals), signals for recognition of viable cells ("dont eat me” signals);
Authors and Affiliations
Rostyslav BILYY
Keywords
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