Characterisation and solubility studies of Quinine sulphate and Hydroxychloroquine sulphate inclusion complexes with α – cyclodextrin
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 11
Abstract
Cyclodextrins are cyclic oligo saccharides which have recently been recognized as useful pharmaceutical excipients. The molecular structure of these glucose derivatives generate a hydrophilic exterior surface and a non -polar cavity interior. Such cyclodextrin can interact with appropriate size drug molecules which lead to the formation of inclusion complexation. The aim of present investigation was to improve the solubility and ultimate bioavailability of Quinine sulphate and hydroxychloroquine sulphate, an antimalarial drug by encapsulating them in α-cyclodextrin. Effect of these complexes was studied by UV- VIS spectroscopy, Fluorescence spectroscopy, phase solubility study, FTIR spectroscopy. The water solubility of these drugs were increased by inclusion with α-CD according to phase solubility diagram. The results obtained from FTIR and 1HNMR spectroscopy confirmed the formation of inclusion complexation into α-cyclodextrin cavity.
Authors and Affiliations
M. Shirly Treasa, Dr. J. Prema kumari
Keywords
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- EP ID EP414431
- DOI 10.9790/5736-1111012434.
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