Characteristiccs of malignant non hogdkin's lymphoma recieved in the onco-haematological unit of Douala General Hospital: Retrospective study over 5 years (2008-2012)
Journal Title: The Journal of Medical Research - Year 2018, Vol 4, Issue 3
Abstract
Malignant Non Hodgkin’s lymphoma (MNHL) is defined as a malignant tumorale disease of lymphoid tissue, characterised by the proliferation of one or two abnormal lymphocyte clones. In Cameroon it is cited among the cancers whose incidence are rising in an alarming manner. It’s frequency is estimated in men at 22 % and in women at 13 %. This retrospective and descriptive study had as aim to describe the epidemiological, clinical and therapeutic profile of malignant non Hodgkin’s lymphoma in the onco-haematological unit of Douala General Hospital over a period of five years. Our selection criteria permitted us to collect 86 cases. The mean age was 42 ±20 years. We noted a male predominance with a sex ratio of 1 ;6. This population came mainly from a low social class (42 cases that is 48.84%). The tumoral syndrome was the most frequent physical sign present (69 cases that is 80.23%). The mean delay in cosultation was about 233.271±251,511 days. At the time of diagnosis, 41 patients that is 47.7% of cases had an activity index ≥ 2. Nodular localisation was predominant 22 cases (25.58%). Among the Extra Nodular localisatio, bone marrow localisation was at the first place 16 cases that is 18.60%). The majority of patients were diagnosed at stage IV of Ann Arbor classification that is 30 cases (34.88%) followed by stage III with 29 cas (33.72%). The predominant histological type was type histologique was that of large cell lymphomas, found in 16 patients (18.60%). Immunohistology was realised in 11 patients (that is 13%). The CHOP protocol was done on CHOP 52 patients that is in 60.50% of cases, followed by RCHOP in 9,30 % of cases. The patients recieved between 1 and 8 cycles. Complete remission was obtained in 32.5% of cases and partial remission in 65,1 % of cases. Half of the patients are alive, 36 % are lost and 14 % are dead. We noted a predominance of these cases having an elevated activity index, a large tumoral syndrome, an Ann Arbor stage of IV and III. The majority of patients are classified as intermediate high risk or high risk. A better knowledge of the clinical presentation will permit us to carry out sensitization actions and better structure our treatment.
Authors and Affiliations
Ngouadjeu Dongho TE, C Tomowiak, G Effa, A Banos, GE Sume, Mouelle Sone A
Keywords
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- EP ID EP531669
- DOI 10.31254/jmr.2018.43011
- Views 100
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