Characterization of lipid spectrum in boys with hypoandrogenism
Journal Title: Український журнал дитячої ендокринології - Year 2018, Vol 0, Issue 3
Abstract
Objective — to identify peculiarities of lipid profile of adolescent boys with hypoandrogenism (HA). Materials and methods. We had under observation 44 boys, aged 13–17 years, with signs of androgen deficiency (delayed puberty). The patients have been examined with assessment of anthropometrical and clinical parameters. In particular, we have conducted a research of blood lipids: total cholesterol (TC), β-lipoproteids (βLP), triglycerides (TG), high-density lipoproteid cholesterol (HDLC) in blood serum with calculation of low-density lipoproteid cholesterol (LDLC) and atherogenic index (AI). Database creation and statistical processing of the results have been performed with «Microsoft Excel» and «SPSS 17.0» application suites. Results and discussion. More than half of the youths with HA (61.4%) have shown pathological changes in level of atherogenically oriented lipids. Analysis of average indices of lipid profile in adolescent boys with HA has identified changes characteristic of atherogenic orientation, because average TC, βLP, TG, and LDLC figures in the group generally were definitely higher than standard values. Analysis of correlational connections between clinical and biochemical hormonal HA parameters has revealed the existence of definite negative connections between TC, LDLC levels and masculinization index, follicle-stimulating hormone level, which got stronger with increase of puberty delay degree. Conclusions. Deviating lipid profile indices in adolescents with HA, predominantly due to increase of proatherogenic and decrease of antiatherogenic lipid fractions, may indicate an impact of androgen deficiency on lipid metabolism in boys, which is important for early diagnosis of lipid metabolism disorders, prevention of cardiovascular and hepatobiliary system abnormalities in youths, future men.
Authors and Affiliations
O. A. Budreiko, G. V. Kosovtsova, Т. P. Kostenko
Keywords
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- EP ID EP460843
- DOI 10.30978/UJPE2018-3-4-45
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