Chemical composition and anti-inflamatory, anti-nociceptive and antipyretic activity of rhizome essential oil of Globba sessiliflora Sims. collected from Garhwal region of Uttarakhand
Journal Title: Journal of Herbal Drugs - Year 2017, Vol 8, Issue 1
Abstract
Background & Aim: Family Zingiberaceae is worldwide in distribution. Plants of the zingiberaceae family are used in traditional herbal folk medicine besides their uses in spices, cosmetic, ornamental, food preservatives etc. In Uttarakhand the herbs grow from sub-tropical to temperate region. Globba sessiliflora Sims rhizomes were collected at maturity stage in November from Garhwal region of Uttarakhand, India. In present communication the medicinal use of various zingiberaceous herb provoked us to study the chemical diversity and pharmacological activity determination of this important traditional herb. Experimental: The essential oil was extracted using hydrodistillation method and analyzed by GC-MS. Anti-inflamatory, anti-nociceptive and antipyretic activities of essential oil were experimently determined using mice model. Results: The major compounds identified were β-eudesmol (27.6%), (E)-β- caryophyllene (24.3%), α-humulene (3.0%), (6E)-nerolidol (4.1%), caryophyllene oxide (9.7%), γ-eudesmol (6.4%) and τ-muurolol (8.3%) besides other minor constituents. Essential oil of G. sessiliflora rhizome showed good anti-inflamatory, anti-nociceptive and antipyretic activities at the dose level of 100 mg/kg body weight. The oral administration of the essential oil exhibited no toxicity at 400, 600 and 800 mg/kg b.wt. concentration. Ibuprofen, indomthacin and paracetamol were used as standard drugs for comparison. Recommended applications/industries: G. sessiliflora essential oil can be used as herbal remedy for its nontoxicity anti-inflamatory, anti-nociceptive and antipyretic activities
Authors and Affiliations
Ravendra Kumar; Prakash Om; Pant Anil K; Kumar Mahesh; Isidorov Valary A; Szczepaniak Lech
Keywords
Related Articles
- EP ID EP23541
- DOI -
- Views 323
- Downloads 18
Effect of hydroalcoholic extract of Nigella sativa L. on the immune system and blood protein components in mice
Background: Black seed (Nigella sativa L.) in traditional medicine is well known that the chemical composition of the immune system with many applications in traditional medicine to fight the infection. This study invest...
Antioxidant effects of strawberry fruits at two phenological stages
Background & Aim: Strawberry (Fragaria vesca L.) is a plant belonging to the Rosaceae family with medicinal properties, including antioxidant activity. The present study aimed at investigating the antioxidant properties...
Antimalarial activities of Breynia Nivosa
Background & Aim: Antiplasmodial activity of leaf extract of Breynia nivosa was evaluated to ascertain the folkloric claim of its antimalarial activity. Experimental: The crude leaf extract (75 – 225 mg/kg), of Breyni...
Chemical compositions of the essential oil from peppermint (Mentha piperita L.) cultivated in Isfahan conditions
Background & Aim: Peppermint (Mentha piperita L.) oil is one of the most popular and widely used as an essential oil. The aim of this study was to identify of the chemical components of peppermint cultivated in Isfahan c...
Optimization of callus induction and cell suspension cultures of Catharanthus roseus
Background & Aim: Investigation of suspension cell culture and callus production in Catharanthus roseus. Catharanthus roseus is an herbaceous perennial plant belongs to the family Apocynaceae. C. roseus is important as c...