Chemicals with Mitochondrial Targets for the Treatment of Neurodegenerative Disorders
Journal Title: Annual Research & Review in Biology - Year 2017, Vol 21, Issue 5
Abstract
Background: Mitochondria are undoubtedly key organelles for the cellular function as the main energy supplier, calcium buffer, and apoptosis mediator. Mitochondrial dysfunction has been identified as a common characteristic in most neurodegenerative diseases, i.e., Alzheimer, Parkinson, and epilepsy. This knowledge has opened a new opportunity for the development of new drugs, testing of natural extracts and, finally, application of nanotechnology in search of beneficial effects on mitochondrial components. Objective: To make a search in databases, and to analyze the latest research on mitochondrial-targeted pharmacological interventions for the treatment of neurodegenerative diseases. Method: We searched the databases; focusing on the latest research reports on the treatment of neurodegenerative disorders with mitochondrial targets, such as antioxidants, inhibitors of mitochondrial permeability transition pore (mPTP), drugs that modify the mitochondrial dynamics, as well as the promising application of nanotechnology in improving drug delivery to the central nervous system. Results: We analyzed over 120 papers for this review. We found evidence of the successful treatment of neurodegenerative diseases in human and experimental models with natural and designed drugs targeting mitochondria. The structure and function is discussed. Conclusion: Mitochondrial dysfunction is a promising target for pharmacological treatment of neurodegenerative diseases. The development of powerful drugs with properties as antioxidants, mitochondrial dynamics and mPTP regulators or design of nanoparticles, all of them with the capacity to reach mitochondria in the central nervous system, preventing neurodegeneration, is becoming a key player in the treatment of neurodegenerative diseases.
Authors and Affiliations
Edna Berzabá-Evoli, Juan Gabriel Tejas-Juárez, Nancy Patricia Gómez-Crisóstomo, Erick Natividad De la Cruz-Hernández, Eduardo Martínez-Abundis
Keywords
Related Articles
- EP ID EP314963
- DOI 10.9734/ARRB/2017/38094
- Views 113
- Downloads 0
Bacteriocins Contributing in Rhizospheric Competition among Fluorescent Pseudomonads
Aims: To examine the production of bacteriocins through the study of a group of rhizospheric Pseudomonas isolates already known to produce metabolites that are antagonistic to fungi. Methodology: Fourteen rhizospheric st...
A Review - Biology, Aquaculture and Medical Use of Seahorse, Hippocampus spp
Seahorse has been used as medicine in Asian countries such as China, Korea, Japan and Vietnam for thousands of years. However, in western countries, the ecology of seahorse has been a focus of attention of many researche...
Genetic Diversity and Distribution of Cassava Brown Streak Virus and Ugandan Cassava Brown Streak Virus in Major Cassava-growing Regions in Kenya
Cassava brown streak disease (CBSD) is caused by two viruses; Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV) that are genetically distinct. The disease can cause losses of up to 100 mill...
Reducing the Histopathological and Biochemical Toxicity of Aflatoxins Contaminated Soybean Using Ozone Treatment
Aims: Soybean which was more frequently used in Egypt for edible oil production and meal for animal feeding was chosen as oil seed. The study targeted to reduce the aflatoxins toxicity, improving safety using natural tre...
Effects of Environmental Stress on Nutrients of Typha domingensis Pers. Plant in Najaf, Iraq
This study determined the natural and environmental characteristics of Baher Al-Najaf Depression (BAND) in Iraq and their effect on nutrients of Typha domingensis as responses to environmental stresses in 4 sites. Sample...