Chiral switches: A Review
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 4
Abstract
Chiral drug are made up of molecule with the same chemical structure, but different three-dimensional arrangements. Modern manufacturing has enabled the development of products containing a single molecular arrangement. The development of these single enantiomers from chiral drugs is known as chiral switching. Enantiomers of the same drug can have different Pharmacodynamics and pharmacokinetic properties. This may translate into potential benefit, such as an improved safety margin, if one of the enantiomers has more favourable therapeutic and pharmacokinetic characteristics. However, some chiral switching has resulted in unpredicted toxicity and the withdrawal of the enantiomer from the marker or a half in its development. Drug companies are increasingly using chiral switching as a marketing strategy. But, before prescribers switch to single enantiomer drugs they should look for evidence from well-conducted clinical trials that show the chiral switch is cost-effective and improves the outcomes for patients rather than patents. Review describes the chiral switching of some compounds and their utility.
Authors and Affiliations
Amit G. Nerkar*, Kedar S. Lade1, Nilam A. Gadhave 2, Sanjay D. Sawant4
Keywords
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