Chitosan/hydroxyapatite scaffolds for tissue engineering manufacturing method effect comparison
Journal Title: Revista Facultad de Ingeniería-Universidad de Antioquia - Year 2015, Vol 1, Issue 75
Abstract
The regeneration of bone is one of the main challenges of modern medicine because many diseases including trauma and tumor can cause bone defects. Tissue engineering (TE) is a promising approach to cure these bone diseases since it allows the reconstruction of tissue by colonization and proliferation of a patient is healthy cells is in an artificial extracellular matrix (scaffolds). The aim of this project was to prepare chitosan/hydroxyapatite CH/HA scaffolds, using various ratios and two different methods: powder hydroxyapatite (commercial) and in situ hydroxyapatite, and then compare their properties. The morphology, chemical composition, and mechanical properties were evaluated by Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), Raman spectroscopy, and compression tests. The scaffolds obtained showed an interconnected porous structure. Scaffolds with better applications in tissue engineering are the scaffolds with chitosan and hydroxyapatite in situ protocol, due to their better morphology; they allow the cell growth. These scaffolds meet the requirements of tissue engineering.
Authors and Affiliations
Diana Marcela Escobar-Sierra, Johan Martins, Claudia Patricia Ossa- Orozco
Keywords
Related Articles
- EP ID EP626402
- DOI 10.17533/udea.redin.n75a04
- Views 104
- Downloads 0
The delay of consequences and perceived risk: an analysis from the workers’ view point
This paper addresses the question of how construction workers perceive occupational risks. It is a question that has not been addressed in scientific research. Specifically, we answer the following research questions: wh...
Physical and mechanical characterization of concrete exposed to elevated temperatures by using ultrasonic pulse velocity
Experimental investigations were carried out for assessing the influence of thermal loadings on the physical and mechanical properties of plain concrete after fire exposure. Cylindrical specimens were subjected to therma...
A two-stage decision support model for a retail distribution center location
This paper proposes a model to support the decision-making process of selecting the location of a distribution center for the retail sector. The model was structured in two stages to consider objective and subjective cri...
Graphene samples preparation and some possible uses in developing optical communication devices
Graphene is a two-dimensional material which has been attracting the attention of worldwide scientific community, motivated by their optical and electronic properties. There are different methods for obtaining grapheme;...
Influence of precipitation scavenging on the PM2.5/PM10 ratio at the Kennedy locality of Bogotá, Colombia
Objective: To establish whether the scavenging effect reduces the PM2.5/PM10 ratio in rainy periods in comparison with dry periods, at the Kennedy locality of Bogotá, Colombia. Materials and methods: Relationships among...