Cholesterol lowering effect of malabar spinach (Amunututu) on egg yolk induced hyper cholesterolaemic rabbits
Journal Title: International Journal of Allied Medical Sciences and Clinical Research - Year 2016, Vol 4, Issue 3
Abstract
Background Basella alba (amunututu) is a common leafy vegetable commonly prepared as soup among the Yoruba ethnic groups. It contains phytochemicals such as tannin, saponin, alkaloid, terpenoid, flavonoid, glycoside, phenolic, vitamins and minerals. Aim and Objective This study was designed to determine the lowering effect of ethanolic and aqueous extract Basella alba on Total cholesterol(CHOL-T), Low Density Lipoprotein-cholesterol(LDL-C),Total Triglycerides(TG-T), High Density Lipoprotein-cholesterol (HDL-C). Materials and Methods Twenty five rabbits weighing 0.7-1.3Kg classified into five experimental groups of 5 rabbits each labeled A, B, C, D(D1, D2), E(E1 and E2) were studied. Control group A were fed with normal feed and water. The extract was carried out using sterile distilled water and ethanol. Each of the extract was administered into some rabbits and was used to treat hypercholesterolemia. The normal rabbit meal was reconstituted to contain 20% egg yolk used for the induction of hypercholesterolemia in some of the rabbits. Plasma concentration of CHOL-T, LDL-C, TG-T, HDL-C was determined using CABAS C111 auto-Chemistry analyzer. Results The result obtained showed a significant decrease in the plasma value of CHOL-T, LDL-T, TG-T after the administration of either ethanolic or aqueous extract in hypercholesterolaemic rabbits and non-hyper cholesterolaemic rabbits(p<0.05). A significantly higher mean plasma value of HDL-C was obtained in hyper cholesterolaemic rabbits fed with 20% egg yolk after the administration of either ethanolic or aqueous extract than in rabbits fed with normal meal with p<0.05. Conclusion The ethanolic or aqueous extracts of Malabar Spinach were found to have a lowering effect on plasma lipids.
Authors and Affiliations
Mathew Folaranmi olaniyan
Keywords
Related Articles
- EP ID EP419835
- DOI -
- Views 61
- Downloads 0
To study the added effect of modified dynamic core stability plank exercise program on diastasis recti abdominis closure and pelvic floor disability :a pilot study
Background and Aim During and after pregnancy, many women experience an increase in the inter-recti abdominal muscle due to stretching and thinning of the linea alba. Because of the synergistic relationship between the p...
Prevalence of suicidal ideation and allied factors among patients with depressive disorder visiting psychiatry outpatient unit of dessie referral hospital, South Wollo, Ethiopia
Background Suicide is the act of intentionally causing one's own death. It is a psychiatric emergency. Depressive disorder continues to be associated with an under-recognized risk for suicidal ideation. Suicidality in de...
Silent but deadly: prevalence of breast problems among female students of secondary school, South Wollo, Ethiopia
Background The growing population in Ethiopia coupled with lifestyle changes will mean an increasing burden of breast problems which are warning signs of cancer. However, oncology services are wholly inadequate-no cancer...
Rugae pattern determination in health and periodontal disease
Background Forensic dentistry is the dental speciality that relates & applies dental knowledge to legal problems. Rugae pattern is as unique to a human as one’s fingerprints & retains its shape throughout life. The anato...
Potential Combination of Cinnamon Type C. Burmanii with C. Cassia as an Antibacterial Alternative in Perineal Wound Infection (Laboratory Study of S. Haemolyticus Culture of Perineum Wounds)
Background Use and misuse of antibiotics in puerperal infections can trigger the emergence of resistant bacteria. To overcome antibiotic resistance, tannin compounds, flavonoids and alkaloids in cinnamon serve as a safe...